Publications

2011

Capuron, L., & Miller, A. H. (2011). Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther, 130(2), 226-238. Abstract

Felger, J. C., Alagbe, O., Pace, T. W., Woolwine, B. J., Hu, F., Raison, C. L., & Miller, A. H. (2011). Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue. Brain Behav Immun, 25(6), 1094-1098. Abstract

Haroon, E., Raison, C. L., & Miller, A. H. (2011). Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior.Neuropsychopharmacology. Abstract

Pace, T. W., & Heim, C. M. (2011). A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities. Brain Behav Immun, 25(1), 6-13. Abstract

Pace, T. W., Hu, F., & Miller, A. H. (2011). Activation of cAMP-protein kinase A abrogates STAT5-mediated inhibition of glucocorticoid receptor signaling by interferon-alpha. Brain Behav Immun. Abstract

Pace, T. W., Wingenfeld, K., Schmidt, I., Meinlschmidt, G., Hellhammer, D. H., & Heim, C. M. (2011). Increased peripheral NF-?B pathway activity in women with childhood abuse-related posttraumatic stress disorder. Brain Behav Immun. Abstract

Raison, C. L., & Miller, A. H. (2011). Is Depression an Inflammatory Disorder? Curr Psychiatry Rep. doi: 10.1007/s11920-011-0232-0 Abstract

Shelton, R. C., & Miller, A. H. (2011). Inflammation in depression: is adiposity a cause? Dialogues Clin Neurosci, 13(1), 41-53. Abstract

2010

Pace, T. W., Negi, L. T., Sivilli, T. I., Issa, M. J., Cole, S. P., Adame, D. D., & Raison, C. L. (2010). Innate immune, neuroendocrine and behavioral responses to psychosocial stress do not predict subsequent compassion meditation practice time. Psychoneuroendocrinology, 35(2), 310-315. Abstract

Pace, T. W. (2010). New pieces for the stress-depression puzzle. Brain Behav Immun, 24(3), 348-349. Abstract

Pace, T.W., Raison, C.L., Miller, A.H. Implications of inflammation for neuropsychiatric disease: contributions and consequences. In Aggarwal, B. (ed), Inflammation, Life Style and Chronic Diseases, Taylor and Francis, LLC, In Press.

Heim, C., Miller, A.H. Depression. In U. Ehlert & R. Von Kaenel (Eds.), Psychoendokrinologie und Psychoimmunologie. Berlin: Springer, in press.

Shelton, R.C., Miller, A.H. Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression, Prog Neurobiol, 91(4):275-99, 2010. Abstract

Raison, C.L., Rye, D.B., Woolwine, B.J., Vogt, G.J., Bautista, B.M., Spivey, J.R., Miller, A.H. Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing and increased evening cortisol. Biol Psychiatry, 68(10):942-9, 2010 NIHMS 200580 Abstract

Orr, A.G., Sharma, A., Binder, N.B., Miller, A.H., Pearce, B.D. Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection. J Mol Neurosci, 41(1):89-96, 2010. Abstract

Musselman, D.L., Miller, A.H., Royster, E.B., McNutt, M.D. Biology of depression and cytokines in cancer. In Kissane, D., Maj, M. and Sartorius, N. (eds.), Depression and Cancer, John Wiley & Sons, Ltd, Hoboken, 2010.

Burke, M.A., Raison, C.L., Miller, A.H. Depression in Cancer: Pathophysiology at the Mind-Body Interface, In Cancer Symptom Science, Eds. Cleeland, C, Fish, M., Dunn, A. Cambridge University Press, NY, 2010.

Miller, A.H. Depression and immunity, a role for T cells? Presidential Address. Brain, Behavior and Immunity, 24(1):1-8, 2010. NIHMS156732 Abstract

Raison, C.L., Borisov, A.S., Woolwine, B.J., Massung, B., Vogt, G., Miller, A.H. Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Molecular Psychiatry, 15:535-547, 2010. Abstract

Raison, C.L., Dantzer, R., Kelley, K.W., Lawson, M., Woolwine, B.J., Vogt, G., Spivey, J.R., Saito, K., Miller, A.H. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Molecular Psychiatry. 15(4):393-403, 2010. NIHMS147985 Abstract

2009

Su, S., Zhao, J., Bremner, J.D., Miller, A.H., Tang, W., Bouzyk, M., Snieder, H., Novik, O., Afzal, N., Goldberg, J., Vaccarino, V. Serotonin transporter gene, depressive symptoms, and interleukin-6. Circ Cardiovasc Genet. 2(6):614-20, 2009. Abstract

Miller, A.H., Pace, T.W.W. Cytokines and glucocorticoid receptor signaling: relevance to major depression. New York Academy of Sciences, 1179:86-105, 2009. Abstract

Capuron, L., Fornwalt, F.B., Knight, B.T., Harvey, P.D., Ninan, P.T., Miller, A.H. Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals? J. Affective Disord, 119(1-3):181-5, 2009. Abstract

Hu, F., Pace, T.W., Miller, A.H. Interferon-alpha inhibits glucocorticoid receptor-mediated gene transcription via STAT-5 activation in mouse HT22 cells. Brain, Behavior and Immunity, 23(4):455-63, 2009. NIHMS 94285 Abstract

Su, S., Miller, A.H., Snieder, H., Bremner, J.D., Ritchie, J., Maisano, C., Jones, L., Murrah, N.V., Goldberg, J., Vaccarino, V. Common genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: the Twins Heart Study. Psychosom Med., 71(2):152-8, 2009. Abstract

Heim, C.M., Young, L.J., Newport, J., Mletzko, T, Miller, A.H., Nemeroff, C.B. Lower CSF oxytocin concentrations in women with a history of childhood abuse. Molecular Psychiatry, 14(10):954-8, 2009. Abstract

Miller, A.H. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. (Norman Cousins Award Lecture). Brain, Behavior and Immunity, 23:149-58, 2009. NIHMS 98177 Abstract

Su, S., Zhao, J., Bremner, J.D., Miller, A.H., Tang, W., Bouzyk, M., Snieder, H., Novik, O., Afzal, N., Goldberg, J., Vaccarino, V. Serotonin transporter gene, depressive symptoms, and interleukin-6. Circ Cardiovasc Genet. 2(6):614-20, 2009. Abstract

Bull SJ, Huezo-Diaz P, Binder EB, Cubells JF, Ranjith G, Maddock C, Miyazaki C, Alexander N, Hotopf M, Cleare AJ, Norris S, Cassidy E, Aitchison KJ, Miller AH, Pariante CM. Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Molecular Psychiatry, 14(12):1095-104, 2009. Abstract

Raison, C.L., Borisov, A.S., Majer, M., Drake, D.F., Pagnoni, G., Woolwine, B.J., Vogt, G., Massung, B., Miller, A.H. Activation of CNS inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biol Psychiatry, 65(4):296-303, 2009. NIHMS 92346 Abstract

Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry, 65(9):732-41, 2009. Abstract

Raison, C.L., Cowles, M.K., Miller, A.H. Immune system and central nervous system interactions. In Sadock B.J., Sadock V.A., and Ruiz P. (eds.), Comprehensive Textbook of Psychiatry/IX, Lippincott Williams and Wilkins, Baltimore, 2009.

Miller, A.H., Pace, T.W.W., Raison, C.L. Neuropsychiatric effects of IFN-alpha: relevance to depression, In Pariante, C.M. (ed), Depression: Translational Approaches to Understanding and Treating, Oxford University Press, Oxford, UK, 2009.

Raison, C.L., Cowles, M.K. Miller, A.H. Brain-Immune System Interactions: Relevance to the Pathophysiology and Treatment of Neuropsychiatric Disorders. In Nemeroff C.B. and Shatzberg A. (eds.), American Psychiatric Press Textbook of Psychopharmacology, 4th Edition, American Psychiatric Press, Inc. Washington, 2009.

Thompson, D.S., Raison, C.L., Jonas, C., Miller, A.H. Cancer and Depression: Phenomenology and Pathophysiology, In: Internal Medicine Care of Cancer Patients. Eds: Gagel, R.F., Escalante, C.P., and Yeung S-C. People's Medical Publishing House, Shelton, CT, 2009.

2008

Cowles, M.K., Miller, A.H. Stress, Cytokines and Depressive Illness, In The New Encyclopedia of Neuroscience, Ed. Squire, L.R., Academic Press, Oxford, 2008.

Alagbe, O., Evans, D.L., Miller, A.H. Nervous, Endocrine and Immune System Interactions in Psychiatry, Textbook of Neuropsychiatry and Clinical Neurosciences. Eds: Hales, R.E., Yudofsky, S.C., Gabbard, G.O. American Psychiatric Press, Inc. Washington, 2008.

Miller, A. H., Raison, C.L. Immune system contributions to the pathophysiology of depression. FOCUS: The Journal of Lifelong Learning in Psychiatry, Volume VI, 36-45, 2008. Abstract

Dantzer, R., Capuron, L., Irwin, M.R., Miller, A.H., Ollat, H., Perry, V.H., Rousey, S., Yirmiya, R. Identification and treatment of symptoms associated with inflammation in medically ill patients. Psychoneuroendocrinology, 33(1): 18-29, 2008. Abstract

Miller, A.H., Ancoli-Israel, S., Bower, J.E., Capuron, L., Irwin, M.R. Neuroendocrine-immune mechanisms of behavioral co-morbidities in patients with cancer. Journal of Clinical Oncology, 26(6): 971-982, 2008. Abstract

Malemud, C.J., Miller, A.H. Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs. Expert Opinion on Therapeutic Targets, 12(2): 171-83, 2008. Abstract

Dai, J., Miller, A.H., Bremner, J.D., Goldberg, J., Jones, L., Shallenberger, L., Buckham, R., Murrah, N.V., Veledar, E., Wilson, P.W., Vaccarino, V. Adherence to the Mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study. Circulation, 117(2): 169-75, 2008. Abstract

Yu, W., Wang, E., Voll, R.J., Miller, A.H., Goodman, M.M. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. Bioorg Med Chem, 16(11): 6145-55, 2008. Abstract

Nater, U.M., Youngblood, L.S., Jones, J.F., Unger, E.R., Miller, A.H., Reeves, W.C., Heim, C. Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome. Psychosom Med, 70(3):298-305, 2008. Abstract

Majer, M., Welberg, L.A., Capuron, L., Pagnoni, G., Raison, C.L., Miller, A.H. IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C. Brain, Behavior, and Immunity, 22(6):870-80, 2008. Abstract

Capuron L, Su S, Miller AH, Bremner JD, Goldberg J, Vogt GJ, Maisano C, Jones L, Murrah NV, Vaccarino V. Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry, 64(10):896-900, 2008. Abstract

Vaccarino V, Brennan ML, Miller AH, Bremner JD, Ritchie JC, Lindau F, Veledar E, Su S, Murrah NV, Jones L, Jawed F, Dai J, Goldberg J, Hazen SL. Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Biological Psychiatry, 64(6):476-83, 2008. Abstract

Yu W, Wang E, Voll RJ, Miller AH, Goodman MM. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. Bioorg Med Chem, 16(11):6145-55, 2008. Abstract

Nater UM, Youngblood LS, Jones JF, Unger ER, Miller AH, Reeves WC, Heim C. Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome. Psychosom Med, 70(3):298-305, 2008. Abstract

Su, S., Snieder, H., Miller, A.H., Ritchie, J., Bremner, J.D., Goldberg, J., Dai, J., Jones, L., Murrah, N.V., Zhao, J., Vaccarino, V. Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis, 200(1):213-20, 2008. Abstract

Majer, M., Welberg, L.A., Capuron, L., Miller, A.H., Pagnoni, G., Reeves, W.C. Neuropsychological performance in persons with chronic fatigue syndrome: results from a population-based study. Psychosom Med. 70(7):829-36, 2008. Abstract

2007

Pace, T.W.W., Hu, F., Miller, A.H. Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain, Behavior and Immunity, 21(1):9-19, 2007. Abstract

Silverman, M.N., Macdougall, M.G., Raison, C.L., Miller, A.H. Endogenous glucocorticoids protect against TNF-alpha-induced increases in anxiety-like behavior in virally-infected mice. Molecular Psychiatry,) 12(4):408-417, 2007. Abstract

Raison, C.L., Woolwine, B.J., Demetrashvili, M.F., Borisov, A.F., Weinreib, R., Staab, J.P., Zajecka, J.M., Bruno, C.J., Henderson, M.A., Reinus, J.F., Evans, D.L., Asnis, G.M., Miller, A.H. Paroxetine for prevention of depressive symptoms induced by interferon-alpha plus ribavirin for hepatitis C. Alimentary Pharmacology and Therapeutics, 25(10):1163-1174, 2007. Abstract

Capuron, L., Pagnoni, G., Demetrashvili, M., Lawson, D.H., Fornwalt, F., Woolwine, B.J., Berns, G.S., Nemeroff, C.B., Miller, A.H.. Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy. Neuropsychopharmacology, 32(11): 2384-92, 2007. Abstract

Sanchez, M.M. Alagbe, O., Felger, J.C., Zhang, J., Graff, A.E., Grand, A.P., Maestripieri, D., Miller, A.H. Activated p38 MAPK is associated with decreased CSF 5-HIAA and increased maternal rejection during infancy in young adult rhesus monkeys, Molecular Psychiatry, 12(10): 895-897, 2007. Abstract

Felger, J.F., Alagbe, O., Hu, F., Mook, D., Freeman, A.A., Sanchez, M.M., Kalin, N.H., Ratti, E., Nemeroff, C.B., Miller, A.H. Effects of interferon-alpha on rhesus monkeys: a non-human primate model of cytokine-induced depression. Biological Psychiatry, 62(11): 1324-1333, 2007. Abstract

2006

Capuron, L., Welberg, L., Heim, C., Wagner, D., Solomon, L., Papanicolaou, D.A., Craddock, R.C., Miller, A.H., Reeves, W.C. Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome. Neuropsychopharmacology. 31(8):1777-1784, 2006 Abstract

Pace, T.W.W., Mletzko, T.C., Alagbe, O., Musselman, D.L., Nemeroff, C.B. Miller, A.H., Heim, C.M. Increased stress-induced plasma IL-6 levels and mononuclear cell NF-kB activation in patients with major depression and increased early life stress. Am J Psychiatry, 163(9):1630-1633, 2006 Abstract

Wang, X., Savage, R., Borisov, A., Rosenberg, R., Woolwine, B., Tucker, M., May, R., Feldman, J., Nemeroff, C.B., Miller, A.H. Efficacy of Risperidone versus Olanzapine in Patients with Schizophrenia Previously on Chronic Conventional Antipsychotic Therapy: A Switch Study. Journal of PsychiatricResearch, 40(7):669-76, 2006. Abstract

Raison, C.L., Capuron, C., Miller, A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends in Immunology, 227:24-31, 2006. Abstract

2005

Miller, A.H., Capuron, L., Raison, C.L. Immunologic influences on emotion regulation. Clin. Neurosci. Res, 4:325-333, 2005. Abstract

Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B.J., Nemeroff, C.B., Berns, G.S., Miller, A.H. Anterior cingulate activation and error processing during interferon-alpha treatment. Biological Psychiatry, 58:190-6, 2005. Abstract

Yoshida, K., Alagbe, O., Wang, X., Woolwine, B., Thornbury, M., Raison, C.L., Miller, A.H. Promoter polymorphisms of the interferon-alpha receptor gene and development of interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings. Neuropsychobiology, 52:55-61, 2005. Abstract

Raison CL. Demetrashvili M. Capuron L. Miller AH. Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs. 19(2):105-23, 2005 Abstract

Hu, F., Wang, X., Pace, T.W.W., Wu, H., Miller, A.H. Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor function, Molecular Psychiatry, 10:426-428, 2005. Abstract

Wang, X., Wu, H., Lakdawala, V.S., Hu, F., Hanson, N.D. and Miller, A.H. Inhibition of Jun N-terminal kinase (JNK) enhances glucocorticoid receptor-mediated function in mouse hippocampal HT22 cells. Neuropsychopharmacology, 30:242-249, 2005. Abstract

Raison, C.L., Borisov, A.S., Broadwell, S.D., Capuron, L.C., Woolwine, B.J., Jacobson, I.M., Nemeroff, C.B., Miller, A.H. Depression during pegylated IFN-alpha plus ribavirin therapy: prevalence and prediction. Journal of Clinical Psychiatry, 66(1):41-8, 2005. Abstract

Raison, C.L., Broadwell, S.D., Borisov, A.S., Manatunga, A.K., Capuron, L.C., Woolwine, B.J., Jacobson, I.M., Nemeroff, C.B., Miller,A.H. Depressive symptoms during IFN-alpha/ribavirin therapy are associated with reduced viral clearance in patients with hepatitis C. Brain Behavior and Immunity, 19(1):23-7, 2005. Abstract

2004

Newport, D.J., Heim, C., Bonsall, R., Miller, A.H., Nemeroff, C.B. Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biological Psychiatry, 55(1):10-20, 2004. Abstract

Asnis, G.M., De La Garza, R. 2nd., Miller, A.H., Raison, C.L. Ribavirin may be an important factor in IFN-induced neuropsychiatric effects. Journal of Clinical Psychiatry, 65(4):581, 2004. Abstract

Frick, B., Capuron, L., Schrocksnadel, K., Musselman, D.L., Lawson, D.H., Nemeroff, C.B. Miller, A.H., Fuchs, D. Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha. Journal of Interferon & Cytokine Research, 24(5):311-7, 2004. Abstract

Lee, B.N., Dantzer, R., Langley, K.E., Bennett, G.J., Dougherty, P.M., Dunn, A.J., Meyers, C.A., Miller, A.H., Payne, R., Reuben, J.M., Wang, X.S., Cleeland, C.S. A cytokine-based neuroimmunological mechanism of cancer-related symptoms. Neuroimmunomodulation, 11(5): 279-292, 2004. Abstract

Capuron, L., Miller, A.H. Cytokines and psychopathology: lessons from interferon alpha. Biological Psychiatry, 56(11):819-24, 2004. Abstract

Silverman, M.N., Miller, A.H., Biron, C.A., Pearce, B.D. Characterization of an IL-6 and ACTH dependent, immune to adrenal pathway during viral infection. Endocrinology, 145(8):3580-9, 2004. Abstract

Scheller-Gilkey, G., Moynes, K., Robinson, I., Kant, C., Miller, A.H. Early life stress and PTSD symptoms in patients with comorbid schizophrenia and substance abuse. Schizophrenia Research, 69(2-3):167-74, 2004. Abstract

Capuron, L., Ravaud, A., Miller, A.H., Dantzer, R. Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy. Brain Behavior and Immunity, 18:205-213, 2004. Abstract

Wang, X., Wu, H., Miller, A.H. Interleukin-1 alpha-induced activation of p38 mitogen-activated kinase inhibits glucocorticoid receptor function, Molecular Psychiatry, 9:65-75, 2004. Abstract

2003

Cleeland, C.S., Bennett, G.J., Dantzer, R., Dougherty, P.M., Dunn, A.J., Meyers, C.A., Miller, A.H., Payne, R., Reuben, J.M., Wang, X.S., Lee, B-N. Are the Symptoms of Cancer and Cancer Treatment due to a Shared Biologic Mechanism? A Cytokine-Immunologic Model of Cancer Symptoms. Cancer, 97:2919-25, 2003. Abstract

Scheller-Gilkey, G., Woolwine, B.J., Robinson, I.C., Gay, O., Moynes, K.A., Miller, A.H. Relationship of clinical symptoms of substance use in schizophrenia patients on conventional versus atypical antipsychotics. American Journal of Drug and Alcohol Abuse, 29(3):553-66, 2003. Abstract

Raison, C.L., Miller, A.H. Cancer and depression: new developments regarding diagnosis and treatment, Biological Psychiatry, 54:283-294, 2003. Abstract

Capuron, L., Neurauter, G., Musselman, D.L., Lawson, D.H., Nemeroff, C.B., Fuchs, D., Miller, A.H. Interferon-Alpha-induced changes in tryptophan metabolism: relationship to depression and paroxetine treatment, Biological Psychiatry, 54:906-914, 2003. Abstract

Raison, C.L, Miller, A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. American Journal of Psychiatry, 160:1554-1565, 2003. Abstract

Capuron, L., Raison, C.L., Lawson, D.H., Musselman, D.L., Su, Y., Nemeroff, C.B. Miller, A.H. An exaggerated HPA axis response to the initial injection of interferon-alpha is associated with depression during interferon alpha therapy, American Journal of Psychiatry.160(7):1342-1345, 2003. Abstract

Newport, D.J., Heim, C., Owens, M.J., Ritchie, J.C., Ramsey, C.H., Bonsall, R., Miller, A.H., Nemeroff, C.B. Cerebrospinal fluid CRF and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis. Neuropsychopharmacology. 28:569-576, 2003. Abstract