Michael Owens PhD
Academic Appointment
- Professor (tenure), Psychiatry and Behavioral Sciences, Emory University, Atlanta
- Faculty, Graduate School of Arts and Sciences, Department of Molecular & Systems Pharmacology, Emory University, Atlanta
- Faculty, Graduate School of Arts and Sciences, Department of Neuroscience, Emory University, Atlanta
Education
Degrees
- PhD Pharmacology & Toxicology from Duke University, Durham
- BS Pharmacy from Duquesne University, Pittsburgh
Research
Focus
- My research focuses on the pharmacology of antidepressant, anxiolytic, and antipsychotic drugs with particular emphasis on neuropeptide transmitters as targets for novel pharmacotherapeutics. Research also focuses on biological markers in the diagnosis and treatment of psychiatric disease, laboratory tests to optimize current psychotropic drug therapy, and the pharmacokinetics of drugs in laboratory animals.
Publications
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Amygdala connectivity is associated with withdrawn/depressed behavior in a large sample of children from the Adolescent Brain Cognitive Development (ABCD) Study.
Psychiatry Res Neuroimaging Volume: 344 Page(s): 111877
10/01/2024 Authors: Thomas E; Juliano A; Owens M; Cupertino RB; Mackey S; Hermosillo R; Miranda-Dominguez O; Conan G; Ahmed M; Fair DA -
Locus Coeruleus Noradrenergic Modulation of Diurnal Corticosterone, Stress Reactivity, and Cardiovascular Homeostasis in Male Rats.
Neuroendocrinology Volume: 112 Page(s): 763 - 776
01/01/2022 Authors: Thrivikraman KV; Kinkead B; Owens MJ; Rapaport MH; Plotsky PM -
Erratum to "Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor" [Bioorg. Med. Chem. 23 (2015) 4286-4302].
Bioorg Med Chem Volume: 28 Page(s): 115660
10/01/2020 Authors: Stehouwer JS; Birnbaum MS; Voll RJ; Owens MJ; Plott SJ; Bourke CH; Wassef MA; Kilts CD; Goodman MM -
Fetal Antidepressant Exposure: Estimated Transporter Occupancy Compared to Drug Concentrations
Volume: 44 Page(s): 314 - 314
12/01/2019 Authors: Kalin M; Cochran A; Newport D; Knight B; Morris N; Ritchie J; Owens M; Stowe Z -
Fetal Antidepressant Exposure and Outcomes
Volume: 85 Page(s): S319 - S319
05/15/2019 Authors: Kalin M; Cochran A; Newport DJ; Knight B; Morris N; Ritchie J; Owens M; Stowe Z -
Test-Retest Reliability of the SERT Imaging Agent 11C-HOMADAM in Healthy Humans.
J Nucl Med Volume: 59 Page(s): 315 - 319
02/01/2018 Authors: Adhikarla V; Dunlop BW; Jarkas N; Goodman MM; Mayberg H; Owens MJ; Nye JA -
Early Life Stress Associated With Increased Striatal N-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass and Behavioral Correlates.
Chronic Stress (Thousand Oaks) Volume: 2
01/01/2018 Authors: Coplan JD; Lu D; El Sehamy AM; Tang C; Jackowski AP; Abdallah CG; Nemeroff CB; Owens MJ; Mathew SJ; Gorman JM -
Adult glucocorticoid receptor mRNA expression volatility in response to an acute stressor and juvenile CSF corticotropin-releasing factor: A pilot neurodevelopmental study.
Neurosci Lett Volume: 647 Page(s): 20 - 25
04/24/2017 Authors: Syed SA; Smith ELP; Batuman O; Rosenblum LA; Owens MJ; Nemeroff CB; Coplan JD -
Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram.
Physiol Behav Volume: 172 Page(s): 24 - 30
04/01/2017 Authors: Neigh GN; Nemeth CL; Kelly SD; Hardy EE; Bourke C; Stowe ZN; Owens MJ -
Exposure to Paliperidone in Utero and via Breast Milk: Drug Clearance and Implications for an Animal Model of Human Exposure
Volume: 41 Page(s): S172 - S172
12/01/2016 Authors: Owens M; Zejnelovic F; Ritchie J; Zhang F; Jin P; Plott S -
In vivo investigation of escitalopram's allosteric site on the serotonin transporter.
Pharmacol Biochem Behav Volume: 141 Page(s): 50 - 57
02/01/2016 Authors: Murray KE; Ressler KJ; Owens MJ -
In Utero Exposure to Clinically Relevant Concentrations of Paliperidone Does Not Affect Several Measures of Development or Early Measures of Cognition in Rats
Volume: 40 Page(s): S127 - S127
12/01/2015 Authors: Owens M; Plott S; Zejnelovik F; Stowe Z; Kinkead B -
Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors.
Bioorg Med Chem Lett Volume: 25 Page(s): 5111 - 5114
11/15/2015 Authors: Stehouwer JS; Bourke CH; Owens MJ; Voll RJ; Kilts CD; Goodman MM -
Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent femalerats.
Neuropharmacology Volume: 97 Page(s): 251 - 258
10/01/2015 Authors: Ehrlich DE; Neigh GN; Bourke CH; Nemeth CL; Hazra R; Ryan SJ; Rowson S; Jairam N; Sholar CA; Rainnie DG -
Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.
Bioorg Med Chem Volume: 23 Page(s): 4286 - 4302
08/01/2015 Authors: Stehouwer JS; Birnbaum MS; Voll RJ; Owens MJ; Plott SJ; Bourke CH; Wassef MA; Kilts CD; Goodman MM -
Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF
1 ) receptor
Bioorganic and Medicinal Chemistry Volume: 23 Page(s): 4286 - 4302
07/23/2015 Authors: Stehouwer JS; Birnbaum MS; Voll RJ; Owens MJ; Plott SJ; Bourke CH; Wassef MA; Kilts CD; Goodman MM -
Corticotropin-Releasing Factor
Encyclopedia of Psychopharmacology Page(s): 447 - 453
01/01/2015 Authors: Murray KE; Bourke CH; Owens MJ -
Erratum to: Prenatal exposure to escitalopram and/or stress in rats : A prenatal stress model of maternal depression and its treatment.
Psychopharmacology (Berl) Volume: 231 Page(s): 4583
12/01/2014 Authors: Bourke CH; Capello CF; Rogers SM; Yu ML; Boss-Williams KA; Weiss JM; Stowe ZN; Owens MJ -
Estimates of Serotonin or Norepinephrine Transporter Occupancy Do Not Predict Antidepressant Response in a 12 Week Trial
Volume: 39 Page(s): S460 - S461
12/01/2014 Authors: Owens M; Dunlop B; Plott S; Zejnelovic F; Craighead WE; Mayberg H; Nemeroff C -
Erratum: Prenatal exposure to escitalopram and/or stress in rats: A prenatal stress model of maternal depression and its treatment (Psychopharmacology (2014) 228:2 (231-241) DOI 10.1007/s00213-013-3030-z)
Psychopharmacology Volume: 231 Page(s): 4583
05/25/2014 Authors: Bourke CH; Capello CF; Rogers SM; Yu ML; Boss-Williams KA; Weiss JM; Stowe ZN; Owens MJ -
CSF Oxytocin (OT) in Maternal Stress: Influence on HPA Axis
Volume: 75 Page(s): 313S - 313S
05/01/2014 Authors: Karim AA; Chandra P; St Germain G; Perera TD; Owens MJ; Nemeroff CB; Coplan JD -
Synthesis, radiosynthesis, and rat microPET evaluation of an F-18 CRF-1 receptor PET tracer
Volume: 55
05/01/2014 Authors: Stehouwer J; Birnbaum M; Voll R; Owens M; Kilts C; Goodman M -
Effects of duloxetine on norepinephrine and serotonin transporter activity in healthy subjects.
J Clin Psychopharmacol Volume: 34 Page(s): 9 - 16
02/01/2014 Authors: Chappell JC; Eisenhofer G; Owens MJ; Haber H; Lachno DR; Dean RA; Knadler MP; Nemeroff CB; Mitchell MI; Detke MJ -
Prenatal antidepressant exposure: clinical and preclinical findings.
Pharmacol Rev Volume: 66 Page(s): 435 - 465
01/01/2014 Authors: Bourke CH; Stowe ZN; Owens MJ -
Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene.
Front Behav Neurosci Volume: 8 Page(s): 342
01/01/2014 Authors: Coplan JD; Fathy HM; Jackowski AP; Tang CY; Perera TD; Mathew SJ; Martinez J; Abdallah CG; Dwork AJ; Pantol G -
Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala.
Psychoneuroendocrinology Volume: 38 Page(s): 1349 - 1361
08/01/2013 Authors: Flandreau EI; Bourke CH; Ressler KJ; Vale WW; Nemeroff CB; Owens MJ -
Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.
Psychopharmacology (Berl) Volume: 228 Page(s): 231 - 241
07/01/2013 Authors: Bourke CH; Capello CF; Rogers SM; Yu ML; Boss-Williams KA; Weiss JM; Stowe ZN; Owens MJ -
Neuroendocrine homeostasis after vagus nerve stimulation in rats.
Psychoneuroendocrinology Volume: 38 Page(s): 1067 - 1077
07/01/2013 Authors: Thrivikraman KV; Zejnelovic F; Bonsall RW; Owens MJ -
Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats.
Neurotoxicol Teratol Volume: 39 Page(s): 100 - 109
01/01/2013 Authors: Bourke CH; Stowe ZN; Neigh GN; Olson DE; Owens MJ -
In vivo dialysis setup with a loop injection valve facilitates retrodialysis studies.
J Pharmacol Toxicol Methods Volume: 68 Page(s): 217 - 224
01/01/2013 Authors: Thrivikraman KV; Kinkead B; Murray KE; Owens MJ -
Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors.
Sci Transl Med Volume: 4 Page(s): 161ra151
11/21/2012 Authors: Rye DB; Bliwise DL; Parker K; Trotti LM; Saini P; Fairley J; Freeman A; Garcia PS; Owens MJ; Ritchie JC -
Wylie W Vale
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: 37 Page(s): 2886 - 2886
11/01/2012 Authors: Nemeroff CB -
Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects.
Biol Psychiatry Volume: 72 Page(s): 238 - 243
08/01/2012 Authors: Coccaro EF; Lee R; Owens MJ; Kinkead B; Nemeroff CB -
Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial.
Trials Volume: 13 Page(s): 106
07/09/2012 Authors: Dunlop BW; Binder EB; Cubells JF; Goodman MM; Kelley ME; Kinkead B; Kutner M; Nemeroff CB; Newport DJ; Owens MJ -
Advances in the neuropsychobiology of suicide
Minerva Psichiatrica Volume: 53 Page(s): 61 - 78
03/01/2012 Authors: Cceda R; Strassnig MT; Nemeroff CB -
Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus.
Psychoneuroendocrinology Volume: 37 Page(s): 27 - 38
01/01/2012 Authors: Flandreau EI; Ressler KJ; Owens MJ; Nemeroff CB -
Depression, antidepressants, and neurogenesis: a critical reappraisal.
Neuropsychopharmacology Volume: 36 Page(s): 2589 - 2602
12/01/2011 Authors: Hanson ND; Owens MJ; Nemeroff CB -
Several stressors fail to reduce adult hippocampal neurogenesis.
Psychoneuroendocrinology Volume: 36 Page(s): 1520 - 1529
11/01/2011 Authors: Hanson ND; Owens MJ; Boss-Williams KA; Weiss JM; Nemeroff CB -
Endogenous GABA(A) Receptor Enhancement Modulates Vigilance in the Primary Hypersomnias
Volume: 70 Page(s): S23 - S23
10/01/2011 Authors: Rye DB; Parker K; Trotti LM; Garcia PS; Ritchie JC; Owens MJ; Morrow L; Bliwise DL; Jenkins A -
Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk.
J Pharmacol Exp Ther Volume: 339 Page(s): 275 - 285
10/01/2011 Authors: Capello CF; Bourke CH; Ritchie JC; Stowe ZN; Newport DJ; Nemeroff A; Owens MJ -
Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine.
J Clin Psychiatry Volume: 72 Page(s): 1124 - 1128
08/01/2011 Authors: Bonne O; Gill JM; Luckenbaugh DA; Collins C; Owens MJ; Alesci S; Neumeister A; Yuan P; Kinkead B; Manji HK -
Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys.
Physiol Behav Volume: 103 Page(s): 535 - 539
07/06/2011 Authors: Coplan JD; Abdallah CG; Mathew SJ; Shungu DC; Mao X; Smith ELP; Kaufman D; Gorman JM; Owens MJ; Nemeroff CB -
Persistent anxiolytic affects after chronic administration of the CRF receptor antagonist R121919 in rats.
Neuropharmacology Volume: 60 Page(s): 1135 - 1141
06/01/2011 Authors: Gutman DA; Owens MJ; Thrivikraman KV; Nemeroff CB -
Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus.
J Pharmacol Exp Ther Volume: 337 Page(s): 180 - 186
04/01/2011 Authors: Hanson ND; Nemeroff CB; Owens MJ -
Gene expression analysis in a rat model of maternal depression and in utero SSRI exposure
Volume: 25
04/01/2011 Authors: Bourke CH; Capello CF; Owens MJ -
Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study.
Psychoneuroendocrinology Volume: 36 Page(s): 289 - 293
02/01/2011 Authors: Coplan JD; Abdallah CG; Kaufman J; Gelernter J; Smith ELP; Perera TD; Dwork AJ; Kaffman A; Gorman JM; Rosenblum LA -
Biological consequences and transgenerational impact of violence and abuse
Psychiatric Times Volume: 27 Page(s): 49 - 52
11/01/2010 Authors: Neigh GN; Ritschel LA; Nemeroff CB -
THE LONG-TERM GENE EXPRESSION EFFECTS OF PRENATAL SSRI EXPOSURE AND/OR PRENATAL STRESS.
Volume: 50 Page(s): 1065 - 1065
09/01/2010 Authors: Bourke CH; Capello CF; Olson DE; Owens MJ -
Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.
J Med Chem Volume: 53 Page(s): 5549 - 5557
08/12/2010 Authors: Stehouwer JS; Daniel LM; Chen P; Voll RJ; Williams L; Plott SJ; Votaw JR; Owens MJ; Howell L; Goodman MM -
Test-retest reliability of the SERT imaging agent [11C]HOMADAM in healthy humans
Volume: 52 Page(s): S110 - S110
08/01/2010 Authors: Nye JA; Owens MJ; Dunlop B; Jarkas N; Mayberg H; Goodman MM -
A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor.
Biol Psychiatry Volume: 67 Page(s): 1212 - 1216
06/15/2010 Authors: Martin EI; Ressler KJ; Jasnow AM; Dabrowska J; Hazra R; Rainnie DG; Nemeroff CB; Owens MJ -
Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress.
J Cereb Blood Flow Metab Volume: 30 Page(s): 1100 - 1104
06/01/2010 Authors: Neigh GN; Owens MJ; Taylor WR; Nemeroff CB -
Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.
Arch Gen Psychiatry Volume: 67 Page(s): 369 - 379
04/01/2010 Authors: Binder EB; Owens MJ; Liu W; Deveau TC; Rush AJ; Trivedi MH; Fava M; Bradley B; Ressler KJ; Nemeroff CB -
The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder
Dopamine Handbook
02/01/2010 Authors: Dunlop BW; Nemeroff CB -
Corticotropin-Releasing Factor
Encyclopedia of Psychopharmacology Page(s): 355 - 360
01/01/2010 Authors: Owens MJ -
Pharmacological treatment of bipolar depression
Practical Management of Bipolar Disorder Page(s): 24 - 32
01/01/2010 Authors: Young AH; Nemeroff CB -
The neuroendocrine effects of early life trauma
The Impact of Early Life Trauma on Health and Disease: The Hidden Epidemic Page(s): 157 - 165
01/01/2010 Authors: LaPrairie JL; Heim CM; Nemeroff CB -
Inflammation and mood disorders: Proinflammatory cytokines and the pathogenesis of depression
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Volume: 9 Page(s): 212 - 220
01/01/2010 Authors: Currier MB; Nemeroff CB -
Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis.
J Cereb Blood Flow Metab Volume: 29 Page(s): 1673 - 1682
10/01/2009 Authors: Neigh GN; Karelina K; Zhang N; Glasper ER; Owens MJ; Plotsky PM; Nemeroff CB; Devries AC -
Reply
Biological Psychiatry Volume: 66 Page(s): e9
09/01/2009 Authors: Thase ME; Nemeroff CB -
The role of serotonin in the pathophysiology of depression: as important as ever.
Clin Chem Volume: 55 Page(s): 1578 - 1579
08/01/2009 Authors: Nemeroff CB; Owens MJ -
Abstract PI-57: Pharmacokinetic/Pharmacodynamic Modeling of Inhibition of Serotonin and Norepinephrine Uptake by Duloxetine and Escitalopram in Healthy Subjects (vol 85, pg S26, 2009)
CLINICAL PHARMACOLOGY & THERAPEUTICS Volume: 86 Page(s): 221 - 221
08/01/2009 Authors: Lobo E; Ernest CS; Detke M; Pangallo B; Knadler MP; Chappell J; Plott S; Owens MJ -
Erratum to "Behavioral effects of the CRF
1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test" [Psychoneuroendocrinology 33(8) (2008) 1093-1101] (DOI:10.1016/j.psyneuen.2008.05.003)
Psychoneuroendocrinology Volume: 34 Page(s): 630 - 631
05/01/2009 Authors: Gutman DA; Coyer MJ; Boss-Williams KA; Owens MJ; Nemeroff CB; Weiss JM -
Security of Attachment as a Function of Maternal Social Rank; Hypothalamo-Pituitary-Adrenal Axis Correlates
Volume: 65 Page(s): 45S - 45S
04/15/2009 Authors: Chandra P; Smith EL; Owens MJ; Nemeroff CB; Rosenblum LA; Coplan JD -
Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes.
Mol Psychiatry Volume: 14 Page(s): 37 - 50
01/01/2009 Authors: Keen-Rhinehart E; Michopoulos V; Toufexis DJ; Martin EI; Nair H; Ressler KJ; Davis M; Owens MJ; Nemeroff CB; Wilson ME -
Neuroendocrinology of Affective Disorders
Encyclopedia of Neuroscience Page(s): 355 - 366
01/01/2009 Authors: Gutman DA; Nemeroff CB -
PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF INHIBITION OF SEROTONIN AND NOREPINEPHRINE UPTAKE BY DULOXETINE AND ESCITALOPRAM IN HEALTHY SUBJECTS
Volume: 85 Page(s): S26 - S26
01/01/2009 Authors: Lobo E; Ernest CS; Detke M; Pangallo B; Knadler MP; Chappell J; Plott S; Owens MJ -
Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
J Med Chem Volume: 51 Page(s): 7788 - 7799
12/25/2008 Authors: Stehouwer JS; Jarkas N; Zeng F; Voll RJ; Williams L; Camp VM; Malveaux EJ; Votaw JR; Howell L; Owens MJ -
Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine.
Neuropsychopharmacology Volume: 33 Page(s): 3201 - 3212
12/01/2008 Authors: Owens MJ; Krulewicz S; Simon JS; Sheehan DV; Thase ME; Carpenter DJ; Plott SJ; Nemeroff CB -
Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test.
Psychoneuroendocrinology Volume: 33 Page(s): 1093 - 1101
09/01/2008 Authors: Gutman DA; Coyer MJ; Boss-Williams KA; Owens MJ; Nemeroff CB; Weiss JM -
The antidepressant sertraline downregulates Akt and has activity against melanoma cells.
Pigment Cell Melanoma Res Volume: 21 Page(s): 451 - 456
08/01/2008 Authors: Reddy KK; Lefkove B; Chen LB; Govindarajan B; Carracedo A; Velasco G; Carrillo CO; Bhandarkar SS; Owens MJ; Mechta-Grigoriou F -
Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats.
Psychoneuroendocrinology Volume: 33 Page(s): 178 - 187
02/01/2008 Authors: Kinkead B; Yan F; Owens MJ; Nemeroff CB -
Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands.
J Med Chem Volume: 51 Page(s): 271 - 281
01/24/2008 Authors: Jarkas N; Voll RJ; Williams L; Votaw JR; Owens M; Goodman MM -
Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.
Bioorg Med Chem Volume: 16 Page(s): 783 - 793
01/15/2008 Authors: Zeng F; Jarkas N; Stehouwer JS; Voll RJ; Owens MJ; Kilts CD; Nemeroff CB; Goodman MM -
Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy.
Psychiatry Res Volume: 157 Page(s): 123 - 129
01/15/2008 Authors: Carpenter LL; Bayat L; Moreno F; Kling MA; Price LH; Tyrka AR; Kinkead B; Owens MJ; Nemeroff CB -
Neuropeptides: biology, regulation and role in neuropsychiatric disorders
Comprehensive Textbook of Psychiatry 9th edition Page(s): 85 - 96
01/01/2008 Authors: Owens MJ; Young LJ; Nemeroff CB -
Preparation of antidepressants for use in preclinical research.
Int J Neuropsychopharmacol Volume: 10 Page(s): 759 - 763
12/01/2007 Authors: McConathy J; Capello C; Jarkas N; Stowe ZN; Owens MJ -
Novel Pharmacologic Treatment of Stress And Addiction: The Role of Crf and Glucocorticoid Antagonists
Stress and Addiction Page(s): 333 - 347
12/01/2007 Authors: Saal D; Nemeroff CB -
New pharmacological tools in evaluation of antidepressant molecules
Volume: 17 Page(s): S610 - S610
10/01/2007 Authors: Owens MJ -
The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal.
Eur J Pharmacol Volume: 571 Page(s): 17 - 24
09/24/2007 Authors: Skelton KH; Oren D; Gutman DA; Easterling K; Holtzman SG; Nemeroff CB; Owens MJ -
Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.
J Med Chem Volume: 50 Page(s): 4553 - 4560
09/20/2007 Authors: Plisson C; Stehouwer JS; Voll RJ; Howell L; Votaw JR; Owens MJ; Goodman MM -
Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes.
Am J Psychiatry Volume: 164 Page(s): 1214 - 1220
08/01/2007 Authors: Newport DJ; Calamaras MR; DeVane CL; Donovan J; Beach AJ; Winn S; Knight BT; Gibson BB; Viguera AC; Owens MJ -
Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents.
Bioorg Med Chem Lett Volume: 17 Page(s): 3044 - 3047
06/01/2007 Authors: Zeng F; Stehouwer JS; Jarkas N; Voll RJ; Williams L; Camp VM; Votaw JR; Owens MJ; Kilts CD; Nemeroff CB -
The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal.
Psychopharmacology (Berl) Volume: 192 Page(s): 385 - 396
06/01/2007 Authors: Skelton KH; Gutman DA; Thrivikraman KV; Nemeroff CB; Owens MJ -
Genetic variants in genes regulating the corticotropin releasing hormone (CRH) system and response to citalopram in the STAR*D sample
Volume: 61 Page(s): 172S - 172S
04/15/2007 Authors: Binder EB; Owens MJ; Liu W; Fava M; Rush AJ; Trivedi MH; Cubells JF; Nemeroff CB -
Corticotropin-Releasing Factor Circuitry in the Brain - Relevance for Affective Disorders and Anxiety
Encyclopedia of Stress Page(s): 630 - 634
01/01/2007 Authors: Gutman DA; Nemeroff CB -
Antidepressant drug-drug interactions: Clinical relevance and risk management
Volume: 12 Page(s): 1 - 11
01/01/2007 Authors: Nemeroff CB; Preskorn SH; DeVane CL -
Stress results in region specific decreases in expression of angiogenic factors in the brain
Volume: 31 Page(s): S161 - S161
12/01/2006 Authors: Neigh GN; Binder EB; Plotsky PM; Owens MJ; Taylor WR; Nemeroff CB -
Trauma spectrum disorders
Principles of Molecular Medicine Page(s): 1203 - 1210
12/01/2006 Authors: Heim C; Bremner JD; Nemeroff CB -
Molecular mechanisms regulating behavior: Focus on genetic and environmental influences
Principles of Molecular Medicine Page(s): 1175 - 1183
12/01/2006 Authors: Ressler KJ; Nemeroff CB -
Lack of physiological regulation of the expression of co-chaperones of the glucocorticoid receptor in periparturn depression
Volume: 31 Page(s): S135 - S135
12/01/2006 Authors: Katz ER; Deveau TC; Capello CF; Owens MJ; Newport DJ; Stowe ZN; Cubells JF; Binder EB -
Stress neurobiology and corticotropin-releasing factor
Psychiatric Times Volume: 23 Page(s): 91 - 95
12/01/2006 Authors: Gutman DA; Gutman AR; Owens MJ; Nemeroff CB -
Could neurotensin receptor antagonists also be antipsychotics?
Volume: 31 Page(s): S244 - S244
12/01/2006 Authors: Caceda R; Kinkead B; Owens MJ; Nemeroff CB -
Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
J Med Chem Volume: 49 Page(s): 6760 - 6767
11/16/2006 Authors: Stehouwer JS; Jarkas N; Zeng F; Voll RJ; Williams L; Owens MJ; Votaw JR; Goodman MM -
Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position.
Bioorg Med Chem Lett Volume: 16 Page(s): 4661 - 4663
09/01/2006 Authors: Zeng F; Jarkas N; Owens MJ; Kilts CD; Nemeroff CB; Goodman MM -
Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities.
J Psychopharmacol Volume: 20 Page(s): 54 - 59
07/01/2006 Authors: DeVane CL; Stowe ZN; Donovan JL; Newport DJ; Pennell PB; Ritchie JC; Owens MJ; Wang J-S -
Medications in pregnancy: Defining exposure
JOURNAL OF WOMENS HEALTH Volume: 15 Page(s): 686 - 686
07/01/2006 Authors: Owens MJ; Stowe ZN -
Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations.
Ann N Y Acad Sci Volume: 1071 Page(s): 525 - 533
07/01/2006 Authors: Coplan JD; Smith ELP; Altemus M; Mathew SJ; Perera T; Kral JG; Gorman JM; Owens MJ; Nemeroff CB; Rosenblum LA -
Cardiac arrest and cardiopulmonary resuscitation increases CRF R1 receptor binding
Volume: 27 Page(s): 12 - 13
05/01/2006 Authors: Neigh GN; Glasper ER; Nemeroff CB; Owens MW; Plotsky PM; DeVries AC -
Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression.
Am J Psychiatry Volume: 163 Page(s): 637 - 643
04/01/2006 Authors: Geracioti TD; Carpenter LL; Owens MJ; Baker DG; Ekhator NN; Horn PS; Strawn JR; Sanacora G; Kinkead B; Price LH -
Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism.
J Neurosci Methods Volume: 151 Page(s): 68 - 81
02/15/2006 Authors: Kinkead B; Selz KA; Owens MJ; Mandell AJ -
Placental passage of tricyclic antidepressants.
Biol Psychiatry Volume: 59 Page(s): 287 - 290
02/01/2006 Authors: Loughhead AM; Stowe ZN; Newport DJ; Ritchie JC; DeVane CL; Owens MJ -
Antidepressants in amniotic fluid: another route of fetal exposure.
Am J Psychiatry Volume: 163 Page(s): 145 - 147
01/01/2006 Authors: Loughhead AM; Fisher AD; Newport DJ; Ritchie JC; Owens MJ; DeVane CL; Stowe ZN -
Serotonin and norepinephrine transporter binding profile of SSRIs.
Essent Psychopharmacol Volume: 7 Page(s): 35 - 41
01/01/2006 Authors: Gutman DA; Owens MJ -
Trauma and depression
Women and Depression: A Handbook for the Social, Behavioral, and Biomedical Sciences Page(s): 360 - 381
01/01/2006 Authors: Penza KM; Heim C; Nemeroff CB -
Virally mediated increased neurotensin 1 receptor in the nucleus accumbens decreases behavioral effects of mesolimbic system activation.
J Neurosci Volume: 25 Page(s): 11748 - 11756
12/14/2005 Authors: Cceda R; Kinkead B; Owens MJ; Nemeroff CB -
The electrophysiological effects of neurotensin on spontaneously active neurons in the nucleus accumbens: an in vivo study.
Synapse Volume: 58 Page(s): 165 - 172
12/01/2005 Authors: Stowe ZN; Landry JC; Tang Z; Owens MJ; Kinkead B; Nemeroff CB -
Variable foraging demand (VFD) exposure of primate maternal-infant dyads and impaired insulin action in juvenile offspring
Volume: 30 Page(s): S154 - S154
12/01/2005 Authors: Coplan JD; Kaufman D; Shorman I; Smith EL; Owens MJ; Nemeroff CB; Rosenblum LA; Kral JG; Banerji M -
Viral vector-induced overexpression of the NT, receptor in the nucleus accumbens: Further evidence for antipsychotic effects of increased NTergic neurotransmission
Volume: 30 Page(s): S48 - S49
12/01/2005 Authors: Nemeroff CB; Caceda R; Owens MJ; Kinkead B -
The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density.
BMC Genet Volume: 6 Page(s): 55
11/27/2005 Authors: VanNess SH; Owens MJ; Kilts CD -
Effects of paroxetine and venlafaxine XR on heart rate variability in depression.
J Clin Psychopharmacol Volume: 25 Page(s): 480 - 484
10/01/2005 Authors: Davidson J; Watkins L; Owens M; Krulewicz S; Connor K; Carpenter D; Krishnan R; Nemeroff C -
Introduction - Developmental neurobiology and psychiatry: Challenges and best practices for studies in children and adolescents
Volume: 66 Page(s): 3 - 4
09/30/2005 Authors: Nemeroff CB; Wagner KD -
Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents.
Nucl Med Biol Volume: 32 Page(s): 593 - 605
08/01/2005 Authors: McConathy J; Owens MJ; Kilts CD; Malveaux EJ; Votaw JR; Nemeroff CB; Goodman MM -
Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand.
CNS Spectr Volume: 10 Page(s): 530 - 536
07/01/2005 Authors: Coplan JD; Altemus M; Mathew SJ; Smith EL; Sharf B; Coplan PM; Kral JG; Gorman JM; Owens MJ; Nemeroff CB -
Genetic analysis of the hypothalamic corticotropin-releasing factor system.
Endocrinology Volume: 146 Page(s): 2362 - 2368
05/01/2005 Authors: Garlow SJ; Boone E; Li W; Owens MJ; Nemeroff CB -
The effect of corticosterone on diurnal differences in rat dorsal raphe gene expression
Volume: 57 Page(s): 27S - 27S
04/15/2005 Authors: Thrivikraman KV; Kinkead B; Gernert KM; Nemeroff CB; Plotsky PM; Owens MJ -
Short-term corticosterone administration does not change erythropoietin receptor expression in the rat hippocampus
Volume: 57 Page(s): 120S - 121S
04/15/2005 Authors: Hanson ND; Jutras M; Plotsky PM; Nemeroff CB; Owens MJ -
Antipsychotic drug-like effects of virally mediated overexpression of the neurotensin 1 receptor in the rat nucleus accumbens
Volume: 57 Page(s): 42S - 43S
04/15/2005 Authors: Caceda R; Kinkead B; Owens MJ; Nemeroff CB -
Serotonin transporter occupancy in rats exposed to SSRIs in utero or via breast milk
Volume: 57 Page(s): 85S - 85S
04/15/2005 Authors: Owens MJ -
The VNTR element in dat1 regulates in vitro DAT density and ligand dissociation constant: Evidence implicating N-linked glycosylation in modulating genotype-dependent effects
Volume: 57 Page(s): 63S - 63S
04/15/2005 Authors: VanNess SH; Owens MJ; Kilts CD -
Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters.
Nucl Med Biol Volume: 32 Page(s): 211 - 224
04/01/2005 Authors: Jarkas N; Votaw JR; Voll RJ; Williams L; Camp VM; Owens MJ; Purselle DC; Bremner JD; Kilts CD; Nemeroff CB -
Corticotropin-releasing factor receptor and glucocorticoid receptor antagonists: new approaches to antidepressant treatment
Current and Future Developments in Psychopharmacology Page(s): 133 - 158
01/01/2005 Authors: Gutman DA; Nemeroff CB; Owens MJ -
Neuropeptides: biology, regulation and role in neuropsychiatric disorders
Kaplan & Sadock's Comprehensive Textbook of Psychiatry Page(s): 72 - 84
01/01/2005 Authors: Owens MJ; Young LJ; Nemeroff CB -
Genetic analysis of hypothalamic corticotropin releasing factor (CRF) system
Volume: 29 Page(s): S140 - S141
12/01/2004 Authors: Boone E; Li W; Owens MJ; Nemeroff CB; Garlow SJ -
Serotonin transporter occupancy in rats exposed to SSRIs in utero or via breast milk
Volume: 29 Page(s): S160 - S161
12/01/2004 Authors: Owens MJ; Capello C; Goren D; Stowe ZN -
Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs.
Neuropsychopharmacology Volume: 29 Page(s): 2200 - 2207
12/01/2004 Authors: Binder EB; Kinkead B; Owens MJ; Nemeroff CB -
The expanding potential clinical utility of CRF, receptor antagonists: From mood and anxiety disorders to drug withdrawal
Volume: 29 Page(s): S44 - S44
12/01/2004 Authors: Nemeroff CB; Owens MJ; Heim C; Newport DJ -
Synchronized maternal-infant elevations of primate CSFCRF in response to variable foraging demand
Volume: 29 Page(s): S96 - S97
12/01/2004 Authors: Coplan JD; Altemus M; Mathew SJ; Smith EL; Scharf B; Coplan PM; Kral JS; Perera T; Dwork A; Gorman JM -
Algorithmically designed allosteric peptides ameliorate behavioral defects in animal model of ADHD
Volume: 29 Page(s): S124 - S124
12/01/2004 Authors: Kinkead B; Selz KA; Owens MJ; Mandell AJ -
Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation.
Psychopharmacology (Berl) Volume: 176 Page(s): 248 - 255
11/01/2004 Authors: Arborelius L; Hawks BW; Owens MJ; Plotsky PM; Nemeroff CB -
A 32-year-old male with suicide attempt
Advanced Studies in Medicine Volume: 4
11/01/2004 Authors: Nemeroff CB -
Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression.
J Neurosci Volume: 24 Page(s): 9303 - 9312
10/20/2004 Authors: Skelton KH; Nemeroff CB; Owens MJ -
Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults.
Biol Psychiatry Volume: 56 Page(s): 531 - 534
10/01/2004 Authors: Tyrka AR; Carpenter LL; McDougle CJ; Kirwin PD; Owens MJ; Nemeroff CB; Strong DR; Price LH -
Development of molecular targets for understanding and treating stress-related disorders
Volume: 14 Page(s): S148 - S149
10/01/2004 Authors: Owens MJ; Hanson N; Gutman DA -
Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter.
Nucl Med Biol Volume: 31 Page(s): 705 - 718
08/01/2004 Authors: McConathy J; Owens MJ; Kilts CD; Malveaux EJ; Camp VM; Votaw JR; Nemeroff CB; Goodman MM -
Synthesis and biological evaluation of [11C]talopram and [11C]talsupram:: candidate PET ligands for the norepinephrine transporter
NUCLEAR MEDICINE AND BIOLOGY Volume: 31 Page(s): 705 - 718
08/01/2004 Authors: McConathy J; Owens MJ; Kilts CD; Malveaux EJ; Camp VM; Votaw JR; Nemeroff CB; Goodman MM -
Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis.
CNS Spectr Volume: 9 Page(s): 23 - 31
06/01/2004 Authors: Nemeroff CB; Owens MJ -
Pharmacologic Differences Among the SSRIs: Focus on the Monoamine Transporters and the HPA Axis
CNS SPECTRUMS Volume: 9 Page(s): 23 - 31
06/01/2004 Authors: Nemeroff CB; Owens MJ -
Hot topics
Serials Librarian Volume: 46 Page(s): 191 - 199
04/19/2004 Authors: Courtney K; Gilbert M; Markwith M; Maxwell K; Brown JR -
The 3 ' VNTR element in dat1 regulates in vitro DAT binding site density
Volume: 55 Page(s): 10S - 10S
04/15/2004 Authors: VanNess SH; Owens MJ; Kilts CD -
Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects.
Neuropsychopharmacology Volume: 29 Page(s): 777 - 784
04/01/2004 Authors: Carpenter LL; Tyrka AR; McDougle CJ; Malison RT; Owens MJ; Nemeroff CB; Price LH -
Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators.
Biophys J Volume: 86 Page(s): 1308 - 1331
03/01/2004 Authors: Selz KA; Mandell AJ; Shlesinger MF; Arcuragi V; Owens MJ -
Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity.
Biol Psychiatry Volume: 55 Page(s): 320 - 322
02/01/2004 Authors: Vaishnavi SN; Nemeroff CB; Plott SJ; Rao SG; Kranzler J; Owens MJ -
Alterations in platelet serotonin transporter binding in women with postpartum onset major depression.
J Psychiatr Res Volume: 38 Page(s): 467 - 473
01/01/2004 Authors: Newport DJ; Owens MJ; Knight DL; Ragan K; Morgan N; Nemeroff CB; Stowe ZN -
Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.
J Clin Psychiatry Volume: 65 Suppl 4 Page(s): 5 - 10
01/01/2004 Authors: Owens MJ -
Pharmacologic differences among the SSRIs: Focus on monoamine transporters and the HPA axis
Volume: 9 Page(s): 23 - 31
01/01/2004 Authors: Nemeroff CB; Owens MJ -
Clinical chemistry
Neurobiology of Mental Illness, 2nd edition Page(s): 141 - 154
01/01/2004 Authors: Owens MJ; Ritchie JC -
Effects of paroxetine and venlafaxine-XR on heart rate variability in depression
Volume: 13 Page(s): S274 - S274
09/01/2003 Authors: Watkins L; Davidson JRT; Connor KM; Beebe KL; Krulewicz S; Abraham K; Zhang W; Owens M; Nemeroff CB -
Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands.
Neuropsychopharmacology Volume: 28 Suppl 1 Page(s): S98 - 107
07/01/2003 Authors: Mandell AJ; Selz KA; Owens MJ; Kinkead B; Shlesinger MF; Gutman DA; Arguragi V -
Broomhead-King hydrophobic modes in receptor-targeted peptide design: how to find modes in a short data sequence
Unsolved Problems of Noise and Fluctuations UPoN 2002: Third International Conference on Unsolved Problems of Noise and Fluctuations in Physics, Biology, and High Technology, Washington, CD, 3-6 September 2002 Page(s): 553 - 559
06/02/2003 Authors: Owens MJ; Mandell AJ; Selz KA; Shlesinger MF -
Broomhead-King Hydrophobic Modes in Receptor-Targeted Peptide Design: How to Find Modes in a Short Data Sequence
Volume: 665 Page(s): 553 - 560
05/28/2003 Authors: Mandell AJ; Selz KA; Owens MJ; Shlesinger MF -
The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems.
J Pharmacol Exp Ther Volume: 305 Page(s): 434 - 439
05/01/2003 Authors: Gilmor ML; Skelton KH; Nemeroff CB; Owens MJ -
Stereochemistry in Drug Action.
Prim Care Companion J Clin Psychiatry Volume: 5 Page(s): 70 - 73
04/01/2003 Authors: McConathy J; Owens MJ -
Elevated levels of central stress mediators in irritable bowel syndrome
Volume: 124 Page(s): A252 - A252
04/01/2003 Authors: Fitzgerald LZ; Chang L; Lee CK; Owens MJ; Mayer M; Naliboff BD; Nemeroff CB; Mayer EA -
Antipsychotic treatment effects on progression of brain pathomorphology in first episode schizophrenia
Volume: 60 Page(s): 293 - 293
03/15/2003 Authors: Lieberman J; Charles HC; Sharma T; Zipursky R; Kahn R; Gur R; Tohen M; Green AI; McEvoy J; Perkins D -
Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis.
Neuropsychopharmacology Volume: 28 Page(s): 569 - 576
03/01/2003 Authors: Newport DJ; Heim C; Owens MJ; Ritchie JC; Ramsey CH; Bonsall R; Miller AH; Nemeroff CB -
The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress.
J Pharmacol Exp Ther Volume: 304 Page(s): 874 - 880
02/01/2003 Authors: Gutman DA; Owens MJ; Skelton KH; Thrivikraman KV; Nemeroff CB -
The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations.
J Clin Psychiatry Volume: 64 Page(s): 73 - 80
01/01/2003 Authors: Stowe ZN; Hostetter AL; Owens MJ; Ritchie JC; Sternberg K; Cohen LS; Nemeroff CB -
Pharmacology of valproate.
Psychopharmacol Bull Volume: 37 Suppl 2 Page(s): 17 - 24
01/01/2003 Authors: Owens MJ; Nemeroff CB -
Neuropharmacology of paroxetine.
Psychopharmacol Bull Volume: 37 Suppl 1 Page(s): 8 - 18
01/01/2003 Authors: Nemeroff CB; Owens MJ -
Reply to Editorial policies on financial disclosure
Nature Neuroscience Volume: 6 Page(s): 1000 - 1001
01/01/2003 Authors: Nemeroff CB; Owens MJ -
Treatment of mood disorders.
Nat Neurosci Volume: 5 Suppl Page(s): 1068 - 1070
11/01/2002 Authors: Nemeroff CB; Owens MJ -
Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine.
Am J Psychiatry Volume: 159 Page(s): 1702 - 1710
10/01/2002 Authors: Gilmor ML; Owens MJ; Nemeroff CB -
Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing.
Stress Volume: 5 Page(s): 185 - 193
09/01/2002 Authors: Mathew SJ; Coplan JD; Smith ELP; Scharf BA; Owens MJ; Nemeroff CB; Mann JJ; Gorman JM; Rosenblum LA -
Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques.
Psychoneuroendocrinology Volume: 27 Page(s): 651 - 660
08/01/2002 Authors: Rosenblum LA; Smith ELP; Altemus M; Scharf BA; Owens MJ; Nemeroff CB; Gorman JM; Coplan JD -
Relationship between CSF corticotropin releasing factor and perceived early life stress in depressed patients and healthy controls
BIOLOGICAL PSYCHIATRY Volume: 51 Page(s): 136S - 137S
04/15/2002 Authors: Carpenter LL; Pelton GH; Malison RT; Owens MJ; Nemeroff CB; Price LH -
Escitalopram: a second-generation SSRI.
CNS Spectr Volume: 7 Page(s): 34 - 39
04/01/2002 Authors: Owens MJ; Rosenbaum JF -
Escitalopram: A Second-Generation SSRI
CNS SPECTRUMS Volume: 7 Page(s): 34 - 39
04/01/2002 Authors: Owens MJ; Rosenbaum JF -
Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment.
J Pharmacol Exp Ther Volume: 300 Page(s): 1085 - 1092
03/01/2002 Authors: Stout SC; Owens MJ; Nemeroff CB -
Stress invalidates reported effects of sodium valproate on brain CRF systems - Response
NEUROPSYCHOPHARMACOLOGY Volume: 26 Page(s): 413 - 414
03/01/2002 Authors: Stout SC; Owens MJ; Nemeroff CB -
Escitalopram: A second-generation SSRI
Volume: 7 Page(s): 34 - 39
01/01/2002 Authors: Owens MJ; Rosenbaum JF -
Response
Neuropsychopharmacology Volume: 26 Page(s): 413 - 414
01/01/2002 Authors: Stout SC; Owens MJ; Nemeroff CB -
The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs.
Biol Psychiatry Volume: 50 Page(s): 856 - 872
12/01/2001 Authors: Binder EB; Kinkead B; Owens MJ; Nemeroff CB -
Neurotensin and dopamine interactions.
Pharmacol Rev Volume: 53 Page(s): 453 - 486
12/01/2001 Authors: Binder EB; Kinkead B; Owens MJ; Nemeroff CB -
CRF receptor antagonists: A new approach to the treatment of depression
Pharmaceutical News Volume: 8 Page(s): 18 - 25
12/01/2001 Authors: Gutman DA; Owens MJ; Nemeroff CB -
Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine.
Biol Psychiatry Volume: 50 Page(s): 345 - 350
09/01/2001 Authors: Owens MJ; Knight DL; Nemeroff CB -
Paroxetine for the prevention of depression induced by interferon alfa.
N Engl J Med Volume: 345 Page(s): 375 - 376
08/02/2001 Authors: Kraus MR; Schfer A; Scheurlen M -
An old transmitter in a new millennium.
CNS Spectr Volume: 6 Page(s): 655
08/01/2001 Authors: Owens MJ; Nemeroff CB -
Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates.
Biol Psychiatry Volume: 50 Page(s): 200 - 204
08/01/2001 Authors: Coplan JD; Smith EL; Altemus M; Scharf BA; Owens MJ; Nemeroff CB; Gorman JM; Rosenblum LA -
Hydrophobic mode-targeted, algorithmically designed peptide ligands as modulators of protein thermodynamic structure and function
Drug-Receptor Thermodynamics Introduction and Applications Page(s): 655 - 700
06/08/2001 Authors: Owens MJ; Mandell AJ; Selz KA; Shlesinger MF; Gutman DA; Arcuragi V -
Effects of sodium valproate on corticotropin-releasing factor systems in rat brain.
Neuropsychopharmacology Volume: 24 Page(s): 624 - 631
06/01/2001 Authors: Stout SC; Owens MJ; Lindsey KP; Knight DL; Nemeroff CB -
Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor.
Nucl Med Biol Volume: 28 Page(s): 187 - 195
02/01/2001 Authors: Martarello L; Kilts CD; Ely T; Owens MJ; Nemeroff CB; Camp M; Goodman MM -
Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating.
J Neurosci Volume: 21 Page(s): 601 - 608
01/15/2001 Authors: Binder EB; Kinkead B; Owens MJ; Kilts CD; Nemeroff CB -
The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis.
Eur J Pharmacol Volume: 411 Page(s): 129 - 134
01/05/2001 Authors: Radke JM; Owens MJ; Nemeroff CB -
Paroxetine in breast milk - Dr. Stowe and colleagues reply
AMERICAN JOURNAL OF PSYCHIATRY Volume: 158 Page(s): 144 - 145
01/01/2001 Authors: Stowe ZN; Cohen LS; Ritchie JC; Owens MJ; Nemeroff CB -
Increased responsiveness to citalopram on 5-HT cell firing in adult rats previously subjected to maternal deprivation
NORDIC JOURNAL OF PSYCHIATRY Volume: 55 Page(s): 88 - 88
01/01/2001 Authors: Arborelius L; Hawks BW; Plotsky PM; Nemefoff CB; Owens MJ -
Are CRF receptor antagonists potential antidepressants?
Hum Psychopharmacol Volume: 16 Page(s): 81 - 87
01/01/2001 Authors: O'Brien D; Skelton KH; Owens MJ; Nemeroff CB -
Neurokinin(1) receptor antagonists as potential antidepressants.
Annu Rev Pharmacol Toxicol Volume: 41 Page(s): 877 - 906
01/01/2001 Authors: Stout SC; Owens MJ; Nemeroff CB -
Contribution of modern neuroscience to developing new treatments for psychiatric disorders
Page(s): 61 - 81
01/01/2001 Authors: Nemeroff CB; Owens MJ -
Contribution of modern neuroscience to developing new treatments for psychiatric disorders in the 21st century
Treatment of Depression Bridging the 21st Century Page(s): 61 - 81
01/01/2001 Authors: Owens MJ -
Atypical antipsychotics
Essentials of Clinical Psychopharmacology Page(s): 125 - 154
01/01/2001 Authors: Owens MJ -
The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain.
Brain Res Dev Brain Res Volume: 124 Page(s): 1 - 10
11/30/2000 Authors: Kinkead B; Owens MJ; Nemeroff CB -
Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: effects of yohimbine and naloxone.
J Clin Endocrinol Metab Volume: 85 Page(s): 4138 - 4145
11/01/2000 Authors: Vythilingam M; Anderson GM; Owens MJ; Halaszynski TM; Bremner JD; Carpenter LL; Heninger GR; Nemeroff CB; Charney DS -
Paroxetine binding to the rat norepinephrine transporter in vivo.
Biol Psychiatry Volume: 48 Page(s): 954 - 956
11/01/2000 Authors: Rubin RT -
Paroxetine binding to the rat norepinephrine transporter in vivo - Reply
BIOLOGICAL PSYCHIATRY Volume: 48 Page(s): 954 - 956
11/01/2000 Authors: Owens MJ; Nemeroff CB; Knight DL -
Sex- and estrous cycle-related differences in the effects of acute antipsychotic drug administration on neurotensin-containing neurons in the rat brain.
J Pharmacol Exp Ther Volume: 295 Page(s): 205 - 211
10/01/2000 Authors: Kinkead B; Lorch SM; Owens MJ; Nemeroff CB -
Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain.
J Pharmacol Exp Ther Volume: 295 Page(s): 67 - 73
10/01/2000 Authors: Kinkead B; Shahid S; Owens MJ; Nemeroff CB -
The neurobiology of urocortin.
Regul Pept Volume: 93 Page(s): 85 - 92
09/25/2000 Authors: Skelton KH; Owens MJ; Nemeroff CB -
Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations.
Psychiatry Res Volume: 95 Page(s): 93 - 102
08/21/2000 Authors: Coplan JD; Smith EL; Trost RC; Scharf BA; Altemus M; Bjornson L; Owens MJ; Gorman JM; Nemeroff CB; Rosenblum LA -
Chronic administration of the selective corticotropin-releasing factor 1 receptor antagonist CP-154,526: behavioral, endocrine and neurochemical effects in the rat.
J Pharmacol Exp Ther Volume: 294 Page(s): 588 - 597
08/01/2000 Authors: Arborelius L; Skelton KH; Thrivikraman KV; Plotsky PM; Schulz DW; Owens MJ -
Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats.
Eur J Pharmacol Volume: 401 Page(s): 39 - 46
07/28/2000 Authors: Stout SC; Mortas P; Owens MJ; Nemeroff CB; Moreau J -
A comparison of plasma alprazolam concentrations following different routes of chronic administration in the Sprague-Dawley rat: implications for psychotropic drug research.
Psychopharmacology (Berl) Volume: 151 Page(s): 72 - 76
07/01/2000 Authors: Skelton KH; Nemeroff CB; Owens MJ -
Paroxetine binding to the rat norepinephrine transporter in vivo.
Biol Psychiatry Volume: 47 Page(s): 842 - 845
05/01/2000 Authors: Owens MJ; Knight DL; Nemeroff CB -
CRF1 receptor antagonists as novel putative antidepressants and anxiolytics
BIOLOGICAL PSYCHIATRY Volume: 47 Page(s): 64S - 64S
04/15/2000 Authors: Nemeroff CB; Owens MJ; Skelton K; Guttman D; Winslow JT; Plotsky PM -
Platelet activation in treatment responders vs. nonresponders in patients with major depression
BIOLOGICAL PSYCHIATRY Volume: 47 Page(s): 77S - +
04/15/2000 Authors: Mussleman DL; Marzec UM; Owens MJ; Reemsnyder AJ; Goodkin RS; Hanson SR; Nemeroff CB -
Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography.
J Med Chem Volume: 43 Page(s): 639 - 648
02/24/2000 Authors: Xing D; Chen P; Keil R; Kilts CD; Shi B; Camp VM; Malveaux G; Ely T; Owens MJ; Votaw J -
Paroxetine in human breast milk and nursing infants.
Am J Psychiatry Volume: 157 Page(s): 185 - 189
02/01/2000 Authors: Stowe ZN; Cohen LS; Hostetter A; Ritchie JC; Owens MJ; Nemeroff CB -
Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems.
J Neurosci Volume: 20 Page(s): 1240 - 1248
02/01/2000 Authors: Skelton KH; Nemeroff CB; Knight DL; Owens MJ -
18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.
Nucl Med Biol Volume: 27 Page(s): 1 - 12
01/01/2000 Authors: Goodman MM; Kilts CD; Keil R; Shi B; Martarello L; Xing D; Votaw J; Ely TD; Lambert P; Owens MJ -
18F-labeled FECNT: A selective radioligand for PET imaging of brain dopamine transporters
Nuclear Medicine and Biology Volume: 27 Page(s): 1 - 12
01/01/2000 Authors: Goodman MM; Kilts CD; Keil R; Shi B; Martarello L; Xing D; Votaw J; Ely TD; Lambert P; Owens MJ -
Corticotropin-releasing factor antagonists as novel psychotherapeutics
Drugs of the Future Volume: 25 Page(s): 923 - 931
01/01/2000 Authors: Gutman DA; Owens MJ; Nemeroff CB -
Neuropeptides: Biology and regulation
Kaplan & Sadock's Comprehensive Textbook of Psychiatry Page(s): 60 - 70
01/01/2000 Authors: Owens MJ; Bissette G; Nemeroff CB -
Nefazodone
Kaplan & Sadock's Comprehensive Textbook of Psychiatry Page(s): 2412 - 2418
01/01/2000 Authors: Owens MJ; Garlow SJ; Kelsey J; Nemeroff CB -
Norepinephrine: Neurotransmitter for the millennium
Volume: 61 Page(s): 3 - 4
01/01/2000 Authors: Nemeroff CB -
Corticotropin-releasing factor antagonists in affective disorders.
Expert Opin Investig Drugs Volume: 8 Page(s): 1849 - 1858
11/01/1999 Authors: Owens MJ; Nemeroff CB -
Corticotropin-releasing factor antagonists: Therapeutic potential in the treatment of affective disorders
CNS Drugs Volume: 12 Page(s): 85 - 92
10/04/1999 Authors: Owens MJ; Nemeroff CB -
Design, synthesis and characterization of fluorinated- and iodinated- pyrrolo[2,3-d]pyrimidines as candidates for CRF1 receptor PET/SPECT ligands
Volume: 42
01/01/1999 Authors: Martarello L; Kilts CD; Ely T; Owens MJ; Nemeroff CB; Goodman MM -
The role of corticotropin-releasing factor in depression and anxiety disorders.
J Endocrinol Volume: 160 Page(s): 1 - 12
01/01/1999 Authors: Arborelius L; Owens MJ; Plotsky PM; Nemeroff CB -
Neurontensin studies in alcohol naive, preferring and non-preferring rats.
Neuroscience Volume: 93 Page(s): 227 - 236
01/01/1999 Authors: Ehlers CL; Somes C; Li TK; Lumeng L; Kinkead B; Owens MJ; Nemeroff CB -
Clinical Chemistry
Neurobiology of Mental Illness Page(s): 132 - 148
01/01/1999 Authors: Owens MJ -
Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography.
Biol Psychiatry Volume: 44 Page(s): 1090 - 1098
12/01/1998 Authors: Malison RT; Price LH; Berman R; van Dyck CH; Pelton GH; Carpenter L; Sanacora G; Owens MJ; Nemeroff CB; Rajeevan N -
Use of psychotropic medications during lactation - Drs. Stowe and Owens reply
AMERICAN JOURNAL OF PSYCHIATRY Volume: 155 Page(s): 1643 - 1644
11/01/1998 Authors: Stowe ZN; Owens MJ -
Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions.
Proc Natl Acad Sci U S A Volume: 95 Page(s): 11462 - 11464
09/15/1998 Authors: Radke JM; Owens MJ; Ritchie JC; Nemeroff CB -
Mode matches in hydrophobic free energy eigenfunctions predict peptide-protein interactions.
Biopolymers Volume: 46 Page(s): 89 - 101
08/01/1998 Authors: Mandell AJ; Owens MJ; Selz KA; Morgan WN; Shlesinger MF; Nemeroff CB -
Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis.
Psychiatr Clin North Am Volume: 21 Page(s): 293 - 307
06/01/1998 Authors: Plotsky PM; Owens MJ; Nemeroff CB -
Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions.
Arch Gen Psychiatry Volume: 55 Page(s): 473 - 477
05/01/1998 Authors: Coplan JD; Trost RC; Owens MJ; Cooper TB; Gorman JM; Nemeroff CB; Rosenblum LA -
Reduced midbrain serotonin transporter binding in major depression as measured by [I-123]beta-CIT SPECT.
JOURNAL OF NUCLEAR MEDICINE Volume: 39 Page(s): 40P - 40P
05/01/1998 Authors: Malison RT; Price LH; Berman R; Pelton GH; Carpenter L; Sanacora G; Owens MJ; Nemeroff CB; Rajeevan N; Baldwin RM -
The HPA axis and the pathophysiology of depression: The role of early adverse
BIOLOGICAL PSYCHIATRY Volume: 43 Page(s): 79S - 80S
04/15/1998 Authors: Nemeroff CB; Owens MJ; Plotsky PM -
Radiolabeled 2 beta-methoxycarbonyl[TC-99m]cyclo-pentadienyltricarbonyl-3 beta-(4-chlorophenyl)tropane (CPTTDAT): Synthesis, characterization and tissue distribution of a radioligand for mapping dopamine transporter sites by SPECT.
Page(s): 103 - 106
01/01/1998 Authors: Xing A; Shi B; Kilts C; Abak T; Camp V; Malveaux E; Ely T; Owens M; Goodman MM -
The serotonin transporter and depression.
Depress Anxiety Volume: 8 Suppl 1 Page(s): 5 - 12
01/01/1998 Authors: Owens MJ; Nemeroff CB -
Atypical Antipsychotics
The American Psychiatric Press Textbook of Psychopharmacology Page(s): 323 - 348
01/01/1998 Authors: Owens MJ; Risch SC -
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
J Pharmacol Exp Ther Volume: 283 Page(s): 1305 - 1322
12/01/1997 Authors: Owens MJ; Morgan WN; Plott SJ; Nemeroff CB -
Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine.
Mol Pharmacol Volume: 52 Page(s): 571 - 581
10/01/1997 Authors: Pariante CM; Pearce BD; Pisell TL; Owens MJ; Miller AH -
Sertraline and desmethylsertraline in human breast milk and nursing infants.
Am J Psychiatry Volume: 154 Page(s): 1255 - 1260
09/01/1997 Authors: Stowe ZN; Owens MJ; Landry JC; Kilts CD; Ely T; Llewellyn A; Nemeroff CB -
The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin-releasing factor.
Ann N Y Acad Sci Volume: 821 Page(s): 194 - 207
06/21/1997 Authors: Heim C; Owens MJ; Plotsky PM; Nemeroff CB -
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.
Am J Psychiatry Volume: 154 Page(s): 624 - 629
05/01/1997 Authors: Bremner JD; Licinio J; Darnell A; Krystal JH; Owens MJ; Southwick SM; Nemeroff CB; Charney DS -
Corticotropin-releasing factor (CRF), CRF-binding protein (CRF-BP), and CRF/CRF-BP complex in Alzheimer's disease and control postmortem human brain.
J Neurochem Volume: 68 Page(s): 2053 - 2060
05/01/1997 Authors: Behan DP; Khongsaly O; Owens MJ; Chung HD; Nemeroff CB; De Souza EB -
Serotonin transporter binding: Pathophysiology and neuropsychopharmacology
BIOLOGICAL PSYCHIATRY Volume: 41 Page(s): 206 - 206
04/01/1997 Authors: Nemeroff CB; Owens MJ -
Pharmacotherapeutic considerations for psychiatric disorders: Depression
Formulary Volume: 32
02/01/1997 Authors: Risby E; Donnigan D; Nemeroff CB -
Persistent changes in corticotropin-releasing factor systems due to early life stress: relationship to the pathophysiology of major depression and post-traumatic stress disorder.
Psychopharmacol Bull Volume: 33 Page(s): 185 - 192
01/01/1997 Authors: Heim C; Owens MJ; Plotsky PM; Nemeroff CB -
Corticotropin-releasing factor, stress, and depression
Neuroscientist Volume: 3 Page(s): 186 - 194
01/01/1997 Authors: Heit S; Owens MJ; Plotsky P; Nemeroff CB -
Neuropeptides in bipolar disorder
Bipolar Disorder: Biological Models and Their Clinical Applications Page(s): 161 - 178
01/01/1997 Authors: Owens MJ; Risby ED; Hartline K; Nemeroff CB -
Managed Care in Psychiatry: Panacea or Pariah?
CNS Spectrums Volume: 2 Page(s): 13 - 62
01/01/1997 Authors: Nemeroff CB -
Depression Must be Invisible
CNS Spectrums Volume: 2 Page(s): 70
01/01/1997 Authors: Nemeroff CB -
Striking a Balance Between Clinical Medical School Departments and the Industry
CNS Spectrums Volume: 2 Page(s): 65 - 66
01/01/1997 Authors: Nemeroff CB -
Striking a Balance With the Pharmaceutical Industry: Part II
CNS Spectrums Volume: 2 Page(s): 68
01/01/1997 Authors: Nemeroff CB -
The Emerging and Disheartening Picture of the Consequences of Child Abuse and Neglect: Implications for Psychiatric Morbidity
CNS Spectrums Volume: 2 Page(s): 68 - 70
01/01/1997 Authors: Nemeroff CB -
Too Much Stuff, Too Little Time
CNS Spectrums Volume: 2 Page(s): 70
01/01/1997 Authors: Nemeroff CB -
Effects of antidepressants on the cytochrome P450 system.
Am J Psychiatry Volume: 153 Page(s): 1655 - 1657
12/01/1996 Authors: Preskorn SH -
Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat.
J Pharmacol Exp Ther Volume: 278 Page(s): 1040 - 1049
09/01/1996 Authors: Owens MJ; Ballenger CA; Knight DL; Nemeroff CB -
Why are these people making a CRF receptor antagonist?
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 212 Page(s): 197 - MEDI
08/25/1996 Authors: Owens MJ -
Incentive bias?
J Clin Psychiatry Volume: 57 Page(s): 265 - 267
06/01/1996 Authors: Lane RM -
Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation.
Endocrinology Volume: 137 Page(s): 1212 - 1218
04/01/1996 Authors: Ladd CO; Owens MJ; Nemeroff CB -
Postmortem and cerebrospinal fluid studies of corticotropin-releasing factor in humans.
Ann N Y Acad Sci Volume: 780 Page(s): 96 - 105
03/22/1996 Authors: Hartline KM; Owens MJ; Nemeroff CB -
Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.
Proc Natl Acad Sci U S A Volume: 93 Page(s): 1619 - 1623
02/20/1996 Authors: Coplan JD; Andrews MW; Rosenblum LA; Owens MJ; Friedman S; Gorman JM; Nemeroff CB -
Peptides and affective disorders
Page(s): 259 - 293
01/01/1996 Authors: Owens MJ; Plotsky PM; Nemeroff CB -
Molecular and cellular mechanisms of antidepressant drugs.
Depress Anxiety Volume: 4 Page(s): 153 - 159
01/01/1996 Authors: Owens MJ -
Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation
Endocrinology Volume: 137 Page(s): 1212 - 1218
01/01/1996 Authors: Ladd CO; Owens MJ; Nemeroff CB -
Selective serotonin reuptake inhibitors in the treatment of depression
Expert Opinion on Investigational Drugs Volume: 5 Page(s): 101 - 108
01/01/1996 Authors: Furman AC; Nemeroff CB -
Peptides and affective disorders
Biology of Schizophrenia and Affective Disorders Page(s): 259 - 293
01/01/1996 Authors: Owens MJ; Plotsky PM; Nemeroff CB -
Molecular and neurobiological mechanisms in the treatment of psychiatric disorders
Psychiatry Page(s): 210 - 257
01/01/1996 Authors: Owens MJ; Mulchahey JJ; Plotsky PM -
Normal pressure pseudotumor cerebri
Journal of Neuro-Ophthalmology Volume: 16 Page(s): 241 - 246
01/01/1996 Authors: Green JP; Newman NJ; Stowe ZN; Nemeroff CB -
Augmentation strategies in patients with refractory depression.
Depress Anxiety Volume: 4 Page(s): 169 - 181
01/01/1996 Authors: Nemeroff CB -
Chronic haloperidol-induced changes in regional dopamine release and metabolism and neurotensin content in rats.
Brain Res Volume: 704 Page(s): 202 - 209
12/18/1995 Authors: See RE; Lynch AM; Aravagiri M; Nemeroff CB; Owens MJ -
Ontogeny of the effect of antipsychotic drug treatment on neurotensin concentrations in the rat brain.
Synapse Volume: 20 Page(s): 244 - 248
07/01/1995 Authors: Kinkead B; Owens MJ; Nemeroff CB -
Regulation of corticotropin-releasing factor secretion and synthesis in the human neuroblastoma clones- BE(2)-M17 and BE(2)-C.
J Neuroendocrinol Volume: 7 Page(s): 461 - 466
06/01/1995 Authors: Kasckow JW; Han JH; Parkes DG; Mulchahey JJ; Owens MJ; Risby ED; Fisher J; Nemeroff CB -
Exposure to an antisense oligonucleotide decreases corticotropin-releasing factor receptor binding in rat pituitary cultures.
J Neurochem Volume: 64 Page(s): 2358 - 2361
05/01/1995 Authors: Owens MJ; Mulchahey JJ; Kasckow JW; Plotsky PM; Nemeroff CB -
REGULATION OF CRF IN BE (2)-M17 AND BE (2)-C NEUROBLASTOMA CELL-LINES
BIOLOGICAL PSYCHIATRY Volume: 37 Page(s): 647 - 647
05/01/1995 Authors: HAN J; KASCKOW JW; PARKES DG; OWENS MJ; STIPETIC MD; BREITMAN D; KAZANJIAN HL; NEMEROFF CB -
The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies.
Life Sci Volume: 57 Page(s): PL373 - PL380
01/01/1995 Authors: Owens MJ; Ieni JR; Knight DL; Winders K; Nemeroff CB -
Immunological, pharmacological, and electrophysiological detection of T-cell-modulating properties of substances of abuse
Methods in Neurosciences Volume: 24 Page(s): 410 - 423
01/01/1995 Authors: Donahoe RM; Madden JJ; Oleson DR; Nemeroff CB -
Neuropeptide alterations in affective disorders: focus on corticotropin releasing hormone, somatostatin and thyrotropin releasing hormone
Psychopharmacology: The Fourth Generation of Progress Page(s): 971 - 982
01/01/1995 Authors: Owens MJ; Plotsky PM; Nemeroff CB -
Atypical Antipsychotics
Textbook of Psychopharmacology Page(s): 263 - 280
01/01/1995 Authors: Owens MJ; Risch SC -
Interleukin-1 alpha induces corticotropin-releasing factor secretion and synthesis from NPLC-KC cells through various second messenger pathways.
Synapse Volume: 18 Page(s): 354 - 358
12/01/1994 Authors: Kasckow JW; Mulcahey JJ; Han JH; Owens MJ; Stipetic MD; Breitman D; Nemeroff CB -
RECOGNITION AND TREATMENT OF DEPRESSION IN A PRIMARY-CARE SETTING
Volume: 55 Page(s): 18 - 34
12/01/1994 Authors: MONTANO CB -
Evolutionary trends in the pharmacotherapeutic management of depression.
Volume: 55 Suppl Page(s): 3 - 15
12/01/1994 Authors: Nemeroff CB -
Apolipoprotein E epsilon 4.
Neurology Volume: 44 Page(s): 2420 - 2421
12/01/1994 Authors: Rama Krishnan KR; Ritchie JC; Tupler LA; McDonald WM; Knight D; Nemeroff CB; Marcovina S -
PHARMACOGENETICS AND DRUG-METABOLISM OF NEWER ANTIDEPRESSANT AGENTS
Volume: 55 Page(s): 38 - 45
12/01/1994 Authors: DEVANE CL -
GUIDELINES FOR THE LONG-TERM TREATMENT OF DEPRESSION
Volume: 55 Page(s): 61 - 69
12/01/1994 Authors: HIRSCHFELD RMA -
THERAPEUTIC CONSIDERATIONS IN TREATING DEPRESSION IN THE ELDERLY
Volume: 55 Page(s): 48 - 58
12/01/1994 Authors: DUNNER DL -
Guidelines for the long-term treatment of depression.
Volume: 55 Suppl Page(s): 61 - 69
12/01/1994 Authors: Hirschfeld RM -
Evolutionary trends in the pharmacotherapeutic management of depression
Volume: 55 Page(s): 3 - 15
12/01/1994 Authors: Nemeroff CB; Dunner DL; Hirschfeld RMA; DeVane CL; Montano CB -
Therapeutic considerations in treating depression in the elderly.
Volume: 55 Suppl Page(s): 48 - 58
12/01/1994 Authors: Dunner DL -
Pharmacogenetics and drug metabolism of newer antidepressant agents.
Volume: 55 Suppl Page(s): 38 - 45
12/01/1994 Authors: DeVane CL -
Recognition and treatment of depression in a primary care setting.
Volume: 55 Suppl Page(s): 18 - 34
12/01/1994 Authors: Montano CB -
Contemporary issues in the management of depression: Introduction
Volume: 97
12/01/1994 Authors: Nemeroff CB -
The effects of typical and atypical antipsychotic drugs on neurotensin-containing neurons in the central nervous system.
J Clin Psychiatry Volume: 55 Suppl B Page(s): 30 - 32
09/01/1994 Authors: Kinkead B; Nemeroff CB -
The BE (2)-M17 neuroblastoma cell line synthesizes and secretes corticotropin-releasing factor.
Brain Res Volume: 654 Page(s): 159 - 162
08/15/1994 Authors: Kasckow JW; Parkes DG; Owens MJ; Stipetic MD; Han JH; Nemeroff CB; Vale WW -
THE BE(2)-C CELL SECRETES CORTICOTROPIN-RELEASING FACTOR AND RESPONDS TO FORSKOLIN
BIOLOGICAL PSYCHIATRY Volume: 35 Page(s): 663 - 663
05/01/1994 Authors: KASCKOW JW; OWENS MJ; HAN J; STIPETIC MD; NEMEROFF CB -
Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.
Clin Chem Volume: 40 Page(s): 288 - 295
02/01/1994 Authors: Owens MJ; Nemeroff CB -
Corticotropin-releasing factor is secreted in the BE(2)-C neuroblastoma cell and is responsive to forskolin.
Life Sci Volume: 54 Page(s): 1825 - 1829
01/01/1994 Authors: Kasckow JW; Owens MJ; Stipetic MD; Han JH; Nemeroff CB -
Depression and anxiety: role of the locus coeruleus and corticotropin-releasing factor.
Brain Res Bull Volume: 35 Page(s): 561 - 572
01/01/1994 Authors: Weiss JM; Stout JC; Aaron MF; Quan N; Owens MJ; Butler PD; Nemeroff CB -
The neurobiological consequences of early traumatic experiences: focus on corticotropin-releasing factor
Volume: 4 Page(s): 255 - 256
01/01/1994 Authors: Nemeroff CB; Owens MJ; Owens CA; Ehlers C; Robbins T; Levine S -
The effects of typical and atypical antipsychotic drugs on neurotensin- containing neurons in the central nervous system
Volume: 55 Page(s): 30 - 32
01/01/1994 Authors: Kinkead B; Nemeroff CB -
Serotonin antagonists as antipsychotics
Serotonin: From Cell Biology to Pharmacology and Therapeutics Page(s): 289 - 296
01/01/1994 Authors: Kinkead BL; Owens MJ; Nemeroff CB -
Effects of gender and social isolation on electroencephalogram and neuroendocrine parameters in rats.
Biol Psychiatry Volume: 33 Page(s): 358 - 366
03/01/1993 Authors: Ehlers CL; Kaneko WM; Owens MJ; Nemeroff CB -
Potential corticotropin-releasing factor pathways in the rat brain as determined by bilateral electrolytic lesions of the central amygdaloid nucleus and the paraventricular nucleus of the hypothalamus.
J Neuroendocrinol Volume: 5 Page(s): 95 - 98
02/01/1993 Authors: Koegler-Muly SM; Owens MJ; Ervin GN; Kilts CD; Nemeroff CB -
SEROTONIN ANTAGONISTS AS ANTIPSYCHOTICS
Volume: 5 Page(s): 289 - 296
01/01/1993 Authors: KINKEAD BL; OWENS MJ; NEMEROFF CB -
The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies.
Ciba Found Symp Volume: 172 Page(s): 296 - 308
01/01/1993 Authors: Owens MJ; Nemeroff CB -
Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor.
Psychoneuroendocrinology Volume: 18 Page(s): 485 - 493
01/01/1993 Authors: Pihoker C; Owens MJ; Kuhn CM; Schanberg SM; Nemeroff CB -
The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: implications for a role for CRF in the pathogenesis of anxiety disorders.
J Psychiatr Res Volume: 27 Suppl 1 Page(s): 209 - 220
01/01/1993 Authors: Owens MJ; Vargas MA; Nemeroff CB -
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN THE PATHOPHYSIOLOGY OF AFFECTIVE AND ANXIETY DISORDERS - LABORATORY AND CLINICAL-STUDIES
CIBA FOUNDATION SYMPOSIA Volume: 172 Page(s): 296 - 316
01/01/1993 Authors: OWENS MJ; NEMEROFF CB -
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN THE PATHOPHYSIOLOGY OF DEPRESSION AND EATING DISORDERS - BASIC AND CLINICAL-STUDIES
Volume: 90 Page(s): 419 - 424
01/01/1993 Authors: OHKUBO Y; OWENS MJ; NEMEROFF CB -
The role of CRF in the pathophysiology of affective disorders: laboratory and clinical studies.
Ciba Foundation Symposium on Corticotropin-Releasing Factor Volume: 172 Page(s): 296 - 316
01/01/1993 Authors: Owens MJ -
The role of corticotropin-releasing factor in the pathophysiology of depression and eating disorders: basic and clinical studies
Primary and Secondary Eating Disorders A Psychoneuroendocrine and Metabolic Approach : Proceedings of the 2nd International Symposium on Disorders of Eating Behaviour Held in Pavia, Italy on 15-19 September 1992 Page(s): 419 - 424
01/01/1993 Authors: Owens MJ; Ohkubo Y; Nemeroff CB -
Preclinical evaluation of the putative antidepressant nefazodone
Depression Volume: 1 Page(s): 315 - 323
01/01/1993 Authors: Owens MJ; Dole KC; Knight DL; Nemeroff CB -
Preliminary studies of 6 beta-hydroxydexamethasone and its importance in the DST.
Biol Psychiatry Volume: 32 Page(s): 825 - 833
11/01/1992 Authors: Ritchie JC; Owens MJ; Mayer H; Watson JT; Kilts C; Carroll BJ -
Effects of chronic ethanol and benzodiazepine treatment and withdrawal on corticotropin-releasing factor neural systems.
Ann N Y Acad Sci Volume: 654 Page(s): 145 - 152
06/28/1992 Authors: Vargas MA; Bissette G; Owens MJ; Ehlers CL; Nemeroff CB -
5 alpha-pregnane-3 alpha, 21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam.
Brain Res Volume: 573 Page(s): 353 - 355
02/28/1992 Authors: Owens MJ; Ritchie JC; Nemeroff CB -
5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam
Brain Research Volume: 573 Page(s): 353 - 355
02/28/1992 Authors: Owens MJ; Ritchie JC; Nemeroff CB -
Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats.
Psychopharmacology (Berl) Volume: 106 Page(s): 359 - 364
01/01/1992 Authors: Ehlers CL; Chaplin RI; Wall TL; Lumeng L; Li TK; Owens MJ; Nemeroff CB -
Stress, corticotropin-releasing factor neurons, and the actions of benzodiazepines.
Clin Neuropharmacol Volume: 15 Suppl 1 Pt A Page(s): 155A - 156A
01/01/1992 Authors: Owens MJ; Nemeroff CB -
Serotonin antagonists as antipsychotic drugs
European Neuropsychopharmacology Volume: 2 Page(s): 287
01/01/1992 Authors: Nemeroff CB; Owens MJ -
EFFECTS OF CHRONIC ETHANOL AND BENZODIAZEPINE TREATMENT AND WITHDRAWAL ON CORTICOTROPIN-RELEASING FACTOR NEURAL SYSTEMS
Volume: 654 Page(s): 145 - 152
01/01/1992 Authors: VARGAS MA; BISSETTE G; OWENS MJ; EHLERS CL; NEMEROFF CB -
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR (CRF) IN THE PATHOGENESIS OF ANXIETY AND AFFECTIVE-DISORDERS - PRECLINICAL AND CLINICAL-STUDIES
Page(s): 915 - 925
01/01/1992 Authors: PIHOKER C; NEMEROFF CB; OWENS MJ; BISSETTE G; WEISS JM; KRISHNAN KRR -
Neuropeptides and mental illness: focus on affective disorders
Biological Psychiatry, Volume 2 Page(s): 543 - 545
01/01/1992 Authors: Owens MJ; Bissette G; Nemeroff CB -
The role of corticotropin-releasing factor (CRF) in the pathogenesis of anxiety and affective disorders: preclinical and clinical studies
Stress: Neurochemical and Molecular Approaches Page(s): 915 - 925
01/01/1992 Authors: Owens MJ; Pihoker C; Nemeroff CB; Bissette G; Weiss JM; Krishnan KRR -
Physiology and pharmacology of corticotropin-releasing factor.
Pharmacol Rev Volume: 43 Page(s): 425 - 473
12/01/1991 Authors: Owens MJ; Nemeroff CB -
Subcellular distribution of corticotropin-releasing-factor-like immunoreactivity in rat central nervous system.
Neuroendocrinology Volume: 54 Page(s): 36 - 41
07/01/1991 Authors: Cain ST; Owens MJ; Nemeroff CB -
The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: acute time course, chronic treatment and abrupt withdrawal.
J Pharmacol Exp Ther Volume: 258 Page(s): 349 - 356
07/01/1991 Authors: Owens MJ; Vargas MA; Knight DL; Nemeroff CB -
Role for brain corticotropin-releasing factor in the weight-reducing effects of chronic fenfluramine treatment in rats.
Endocrinology Volume: 128 Page(s): 3237 - 3246
06/01/1991 Authors: Appel NM; Owens MJ; Culp S; Zaczek R; Contrera JF; Bissette G; Nemeroff CB; De Souza EB -
Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity.
Neuropsychopharmacology Volume: 4 Page(s): 87 - 93
02/01/1991 Authors: Owens MJ; Overstreet DH; Knight DL; Rezvani AH; Ritchie JC; Bissette G; Janowsky DS; Nemeroff CB -
The 5-hydroxytryptamine2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. II. Biochemical and physiological evidence for the development of tolerance after chronic administration.
J Pharmacol Exp Ther Volume: 256 Page(s): 795 - 800
02/01/1991 Authors: Owens MJ; Knight DL; Ritchie JC; Nemeroff CB -
The 5-hydroxytryptamine2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. I. Acute effects on HPA axis activity and corticotropin-releasing factor-containing neurons in the rat brain.
J Pharmacol Exp Ther Volume: 256 Page(s): 787 - 794
02/01/1991 Authors: Owens MJ; Knight DL; Ritchie JC; Nemeroff CB -
NEUROPEPTIDES AND MENTAL-ILLNESS - FOCUS ON AFFECTIVE-DISORDERS
Volume: 968 Page(s): 543 - 545
01/01/1991 Authors: BISSETTE G; OWENS MJ; NEMEROFF CB -
Horizons in Endocrinology
Horizons in Endocrinology Volume II. Serono Symposia 76, Page(s): 83 - 88
01/01/1991 Authors: Owens MJ; Pihoker C; Nemeroff CB; Cain ST -
Corticotropin-releasing factor concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone.
Neuroendocrinology Volume: 52 Page(s): 626 - 631
12/01/1990 Authors: Owens MJ; Bartolome J; Schanberg SM; Nemeroff CB -
Effects of 5-HT1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain.
Eur J Pharmacol Volume: 190 Page(s): 113 - 122
11/06/1990 Authors: Owens MJ; Edwards E; Nemeroff CB -
Neuropeptide involvement in affective disorders
Current Opinion in Psychiatry Volume: 3 Page(s): 108 - 112
09/05/1990 Authors: Nemeroff CB -
Neurosciences and neuropsychiatry: Editorial overview
Current Opinion in Psychiatry Volume: 3 Page(s): 73 - 74
09/05/1990 Authors: Deakin JFW; Nemeroff CB -
Evidence for a role for corticotropin-releasing factor in the pathogenesis of anxiety disorders and in the action of triazolobenzodiazepines
Journal of Psychiatric Research Volume: 24 Page(s): 90 - 91
01/01/1990 Authors: Nemeroff CB; Weiss JM; Bissette G; Owens MJ -
Ecological toxicology and human health effects of heptachlor.
Rev Environ Contam Toxicol Volume: 111 Page(s): 61 - 142
01/01/1990 Authors: Fendick EA; Mather-Mihaich E; Houck KA; St Clair MB; Faust JB; Rockwell CH; Owens M -
CNS Peptide Mechanisms in Stress and Depression
CNS Peptide Mechanisms in Stress and Depression Page(s): 73 - 92
01/01/1990 Authors: Owens MJ; Vargas MA; Nemeroff CB -
Growth hormone response to growth hormone releasing factor in Alzheimer's disease.
Neuroendocrinology Volume: 50 Page(s): 663 - 666
12/01/1989 Authors: Nemeroff CB; Krishnan KR; Belkin BM; Ritchie JC; Clark C; Vale WW; Rivier JE; Thorner MO -
Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain.
Synapse Volume: 4 Page(s): 196 - 202
01/01/1989 Authors: Owens MJ; Bissette G; Nemeroff CB -
Preclinical and clinical investigations of corticotropin releasing factor: assessment of its role in depressive disorders
New Directions in Affective Disorders Page(s): 262 - 266
01/01/1989 Authors: Owens MJ; Nemeroff CB -
Corticotropin releasing factor: possible involvement in the pathogenesis of affective disorders
Molecular biology of stress proceedings of a director's sponsors-UCLA symposia held at Keystone, Colorado, April 10-17, 1988 Page(s): 67 - 76
01/01/1989 Authors: Owens MJ; Bond PE; Butler PD; Bissette G; Nemeroff CB -
Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.
Arch Gen Psychiatry Volume: 45 Page(s): 577 - 579
06/01/1988 Authors: Nemeroff CB; Owens MJ; Bissette G; Andorn AC; Stanley M -
Preclinical and clinical studies with corticotropin-releasing factor: implications for affective disorders.
Psychopharmacol Bull Volume: 24 Page(s): 355 - 359
01/01/1988 Authors: Owens MJ; Nemeroff CB -
The neurobiology of corticotropin releasing factor (CRF): Implications for affective disorders.
The Hypothalamic-pituitary-adrenal Axis Physiology, Pathophysiology, and Psychiatric Implications Page(s): 1 - 36
01/01/1988 Authors: Owens MJ; Nemeroff C -
Recent advances in the neurobiology of neuropeptides: focus on corticotropin releasing factor
Biological Psychiatry 1985 Proceedings of the IVth World Congress of Biological Psychiatry Held from September 8th Through 13th, 1985 in Philadelphia, Pennsylvania, U.S.A Page(s): 103 - 105
01/01/1986 Authors: Owens MJ; Nemeroff CB