Principal Investigator: Helen S. Mayberg, MD
Population: Treatment-resistant depression
Summary: DBS for TRD is a neurosurgical intervention for depression resistant to standard interventions, including psychotherapy, medication combinations, and electroconvulsive therapy (ECT). The study requires a long-term commitment, as patients are closely monitored with weekly visits to various study sites 4 weeks prior to surgery and 7 months following surgery. At the end of the 7 month period following surgery, patients are followed for five years via visits every month, 3 months, or 6 months, at the discretion of the study psychiatrists.