Principal Investigator: Katrina Johnson, PhD (Sponsor: D. Jeff Newport, MD)
Population: Pregnant women with a lifetime diagnosis of unipolar depression (may be currently euthymic or depressed) and pregnant women with no lifetime Axis I disorder.
Summary: Patients will be seen 3 times during pregnancy, ideally at 18, 24 and 36 weeks. The initial screening visit lasts about 2 hours and the remaining prenatal visits last about 1 hour. Mothers and their newborns will be seen 1-2 weeks postpartum.
Procedure: Prenatal visits will include a diagnostic assessment and measures of mood, stress, and health behaviors. Newborns will have a neurobehavioral exam and 15-minute non-sedated MRI at Egleston.