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Research at the ECNRU

To participate in research call (404) 712-2014; or email inquiries to Stacy at sladd2@emory.edu

Our Current Studies

*Neural Circuits in Women with Abuse and PTSD
This study supported by the National Institute of Mental Health looks at brain function and structure with MRI and PET
before and after treatment with paroxetine or placebo for three months followed by free treatment with paroxetine for three months.
Call Carolina Lecours for information: 404.712.9536 or email clecour@emory.edu

*Mechanisms of Depression in CVD
This study, funded by the National Heart Lung and Blood Institute looks at brain activation and myocardial blood flow in patients with heart disease with and without depression during a stressful task. Preliminary results showed that patients with coronary heart disease (CHD) and depression with a history of exposure to psychological trauma showed increased myocardial ischemia during a stressful task.
Call Kelly Tracey for information 404.712.2059 or email kelly.tracey@emory.edu

Memory and the Hippocampus in Vietnam-Era Twins with Posttraumatic Stress Disorder
This VA funded study compares twins with and without PTSD for hippocampal volume measured with MRI, and hippocampal activation with PET. Our initial analysis showed a 9% reduction in hippocampal volume in PTSD twins compared to their non-PTSD brothers.

*Early Intervention for PTSD in Iraq Veterans
In a study funded by the Veterans Administration we are looking at the effects of early treatment for PTSD in returning Iraq veterans.
Call Ardith DeShay for information 404.712.9661 or email adeshay@emory.edu

*Benzodiazepine Receptor in PTSD
This project uses PET imaging of the benzodiazpine receptor in returning Iraq vets with PTSD. Call Majid Shah MD for information. 404.727.4117 or email mhshah@emory.edu

*Neural Correlates of Early Intervention for PTSD
This DOD-funded project looks at changes in the brain with treatment for PTSD. Returning veterans from Iraq undergo brain imaging before and after treatment for PTSD.
Call Stacy Ladd for information, 404-712-2014 or email sladd2@emory.edu

Early Intervention with MBSR for PTSD in Iraq Veterans
This project looked at the effects of Mindfulness Based Stress Reduction (MBSR) for PTSD in returning Iraq veterans. Data is currently being analyzed.

Effects of Captivity Stress on Cardiovascular Disease
This project was initially funded by the Department of Defense to study myocardial perfusion with SPECT and other markers of 'allostatic load', looking at factors affecting risk and resiliency for health outcomes in Repatriated Prisoners of War (RPOWs) at the Robert Mitchell Center for RPOWs, Pensacola Naval Airstation, Pensacola FL.

*Brain Metabolic Correlates of Vulnerability to Depressive Relapse in Patients with Major Depression
Thanks to the National Alliance for Research on Schizophrenia and Depression (NARSAD) we are able to conduct a study to treat depressed patients with duloxetine and then induce a depressive relapse with tryptophan depletion and compare brain function with depletion versus a placebo. Based on our prior work we found that patients with an increased resting limbic brain metabolism were at increased risk for depletion induced relapse, and previous studies showed that patients with depletion induced relapse are at increased risk for relapse if they go off of their medications. We predict that patients with this signal of increased resting
limbic metabolism will be more likely to relapse.

*we are seeking volunteers for these studies. We pay for participation.